Epicardial Adipose Tissue: Another Tassel in the Complex Fabric of Atherosclerosis.

N. Alexopoulos, P. Raggi
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引用次数: 8

Abstract

Atherosclerosis affects the majority of adult individuals in industrialized nations and it is beginning to affect even traditionally spared populations. The classic view has been that the precipitating events are intraluminal. However, good evidence supports the possibility that at least part of the atherosclerosis burden may be the consequence of extra-luminal noxious stimuli. Additionally, the epidemic of obesity, insulin resistance and diabetes mellitus has generated a strong interest in the potential role of visceral adipose tissue as an extra-luminal promoter of atherosclerosis. The epicardial space is filled with adipose tissue with an embryological origin similar to that of abdominal visceral fat. Both fats are highly inflamed in obese patients, patients with the metabolic syndrome and in those with established coronary artery disease. Additionally they are capable of secreting large quantities of pro-inflammatory cytokines and free fatty acids but also anti-inflammatory adipokines like adiponectin. In this manuscript we review the current evidence supporting the role of epicardial adipose tissue in the development of atherosclerosis and its complications.
心外膜脂肪组织:动脉粥样硬化复杂结构中的另一个流苏。
动脉粥样硬化影响工业化国家的大多数成年人,甚至开始影响传统上幸免的人群。经典观点认为,促成事件发生在腔内。然而,良好的证据支持至少部分动脉粥样硬化负担可能是腔外有害刺激的结果。此外,肥胖、胰岛素抵抗和糖尿病的流行已经引起了人们对内脏脂肪组织作为动脉粥样硬化管外促进剂的潜在作用的强烈兴趣。心外膜间隙充满脂肪组织,其胚胎起源与腹部内脏脂肪相似。肥胖患者、代谢综合征患者和已确诊的冠状动脉疾病患者的这两种脂肪都高度发炎。此外,它们能够分泌大量的促炎细胞因子和游离脂肪酸,还能分泌抗炎脂肪因子,如脂联素。在这篇文章中,我们回顾了目前支持心外膜脂肪组织在动脉粥样硬化及其并发症发展中的作用的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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