Ethyl Acetate Fraction of Total Phenols from Zanthoxylum zanthoxyloides Leaves Treated Alloxan-Induced Diabetic Albino Rats

International Journal of Biochemistry Research & Review Pub Date : 2021-10-21 DOI:10.9734/ijbcrr/2021/v30i630273

C. O. Ekwemba, N. Nwachukwu, C. Ibegbulem

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Abstract

Aims: Ethyl acetate fraction of total phenols from Zanthoxylum zanthoxyloides leaves was evaluated for its effects in alloxan-induced diabetic male albino rats. Methodology: Diabetes was induced in rats by administrating alloxan monohydrate at a dose of 130 mg/kg body weight. The ethyl acetate fraction was administered to rats at 100, 200 and 400 mg/kg b.w. daily for 15 days. Blood glucose, lipid profile and pancreatic histopathology were monitored using standard methods. Results: Results indicated that two weeks after treatment with Z. zanthoxyloides, significant (p<0.05) reductions in hyperglycemic blood glucose, total cholesterol and low-density lipoproteins (LDL) were recorded; with lowest values recorded in the group treated with the highest concentration of the extract. Histopathological examination of pancreatic tissues supported the protective effect of Z. zanthoxyloides phenol extract against diabetic damage. Conclusion: In conclusion, total phenols of Z. zanthoxyloides exerted antidiabetic effects in alloxan-induced diabetic rats and protected pancreatic tissues from diabetic damage.

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花椒叶总酚乙酸乙酯部分治疗四氧嗪诱导的糖尿病白化大鼠

目的:评价花椒叶总酚乙酸乙酯部位对四氧嗪诱导的雄性白化糖尿病大鼠的作用。方法:给药130 mg/kg体重的一水四氧嘧啶诱导大鼠糖尿病。大鼠分别按100、200和400 mg/kg b.w.每日给药15 d。采用标准方法监测血糖、血脂和胰腺组织病理学。结果:结果显示，治疗2周后，大鼠高血糖、总胆固醇、低密度脂蛋白(LDL)明显降低(p<0.05);用最高浓度提取物处理的组记录的数值最低。胰腺组织病理学检查支持花椒酚提取物对糖尿病损伤的保护作用。结论:花椒总酚对四氧嘧啶诱导的糖尿病大鼠具有抗糖尿病作用，对胰腺组织有保护作用。

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International Journal of Biochemistry Research & Review

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