HEPATOPROTECTIVE EFFECT OF N-ACETYLCYSTIENE ON THE TOXIC HAZARDS OF TITANIUM DIOXIDE NANOPARTICLES

American Journal of Pharmacology and Toxicology Pub Date : 2013-09-26 DOI:10.3844/AJPTSP.2013.141.147

H. Attia, M. Soliman, G. Abdel-Rahman, M. Nassan, S. Ismail, Mona M. Farouk, C. Solcan

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引用次数: 21

Abstract

The present study was directed to evaluate the toxic effects of orally administered titanium dioxide naonparticles (TiO2) on liver of male albino rats and to evaluate the ameliorative effects of N-acetylcysteine (NAC). Forty adult male albino rats were divided into 4 groups; control group, NAC group, TiO2 group and TiO2/ NAC group. Rats were administered either TiO2 (1200 mg kg-1 BW) or NAC (100 mg kg-1 BW) alone or together for 9 months. Blood was taken to evaluate serum changes in GPT, GOT and MDA levels. Liver tissues were examined for changes in MDA, GSH and changes in liver histopathology. Administration of TiO2 increased serum GPT, GOT and decreased MDA levels. Co-treatment of rats with NAC and TiO2 improved such significant changes induced by TiO2 alone. Moreover, significant time dependent increase in MDA and decrease in GSH levels in liver tissues were recorded. Liver histopathology showed vacuolar, hydropic degeneration and cell death of some hepatic cells. In conclusion, results confirmed the protective effect of NAC in amelioration of the biohazard effects induced by TiO2 in rats.

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n -乙酰半胱氨酸对二氧化钛纳米颗粒毒性危害的肝保护作用

本研究旨在评价口服二氧化钛纳米颗粒(TiO2)对雄性白化大鼠肝脏的毒性作用，并评价n -乙酰半胱氨酸(NAC)的改善作用。40只成年雄性白化大鼠分为4组;对照组、NAC组、TiO2组和TiO2/ NAC组。给大鼠单独或联合给予TiO2 (1200 mg kg-1 BW)或NAC (100 mg kg-1 BW) 9个月。取血评估血清GPT、GOT和MDA水平的变化。检测肝组织丙二醛、谷胱甘肽的变化及肝组织病理学变化。TiO2可提高血清GPT、GOT水平，降低MDA水平。NAC和TiO2共处理大鼠，改善了单独TiO2诱导的这种显著变化。此外，肝组织中MDA升高和GSH降低的时间依赖性显著。肝组织病理学表现为部分肝细胞空泡、水变性及细胞死亡。综上所述，NAC具有改善TiO2对大鼠生物危害的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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American Journal of Pharmacology and Toxicology

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