Inflammatory Biomarkers And Endothelial Dysfunction Among Obese Type 2 Diabetic Patients: A Correlational Study

Abstract

Background:The vascular complications of diabetes mellitus impose a huge burden on the management of this disease. Inflammation is one of the major factors in the formation of endothelial dysfunction. Endothelial dysfunction is a major contributor to the complications of diabetes mellitus.Objective:The aim of the present study was to investigate the possible relationship between inflammation and endothelial dysfunction in obese type 2 diabetic patients.Material and Methods:Forty obese type 2 diabetic patients (24 males and 16 females) with body mass index (BMI) ranged from 31 to 35 Kg/m2, non-smokers, free from respiratory, kidney; liver, metabolic and neurological disorders were recorded in this study. Their age ranged from 40 to 55 years were included in this study as the first group (A). While a forty non-diabetic subjects (23 males and 17 females) not suffering of any disease, their age ranged from 40 to 52 years were included in this study as the second group (B) and considered as a control group.Results:Diabetic patients showed significantly higher values of TNF-α, IL-6, CRP, HBA1c, ICAM-1, VCAM-1 and E-selectin in comparison to controls. Also, there was significant positive correlation between inflammatory and endothelial dysfunction biomarkers among obese diabetic patients.Conclusions:There was a strong association between elevated biomarkers of inflammation and endothelial dysfunction among type 2 diabetic patients.