Role of Ascitic Fluid Polymorphic Nuclear Cell Count and Prostaglandin E2 Prognostic Outcome of Cirrhotic Diseased Individual's Mortality

Q4 Medicine

Surgery, Gastroenterology and Oncology Pub Date : 2023-01-01 DOI:10.21614/sgo-514

Abdel-Naser Abdel-Atty Gad Allah, Radwa Essam Abbas, Ashraf Ghareib Dala, Shaimaa Elsayed Ramadan, Hany Abdelbary AbdelAziz

{"title":"Role of Ascitic Fluid Polymorphic Nuclear Cell Count and Prostaglandin E2 Prognostic Outcome of Cirrhotic Diseased Individual's Mortality","authors":"Abdel-Naser Abdel-Atty Gad Allah, Radwa Essam Abbas, Ashraf Ghareib Dala, Shaimaa Elsayed Ramadan, Hany Abdelbary AbdelAziz","doi":"10.21614/sgo-514","DOIUrl":null,"url":null,"abstract":"Background: One of the most common and dangerous consequences in individuals with decompensated cirrhosis is SBP. Early antibiotic treatment is crucial for effective treatment and lowering death rate. A modulator of the immune response and infection is PGE2. Aim of the Study: To analyze how Prostaglandin E2 and the ascites polymorphic nuclear cell count affect cirrhotic diseased individual mortality prognosis. Material and Methods: Ninety diseased individuals were chosen from the wards of the Internal Medicine Department of Menoufia University Hospitals, the NLI of Menoufia University, and the El Helal Health Insurance Hospital in Shibin Al-Kum for this prospective diagnostic test study. Two cohorts of participants were formed. Cohort I: 45 diseased individuals with hepatic cirrhosis and SBP, as well as 45 diseased individuals without SBP. All diseased individuals had a history review, MELD and CTP scores, a pelvic-abdominal ultrasound, and laboratory investigations such as serum, CBC with differentials made by CRP and ESR, INR and prothrombin time, SAAG, serum creatinine and urea, and liver function tests (ALT and AST), GGT, and Alk.pho. PMN and serum ascitic fluid prostaglandin E2 are included in ascitic fluid analyses. Results: While ascitic fluid PGE2 was elevated in the non-SBP cohort, PMN cell count was elevated in the SBP cohort. Regarding ascitic fluid PGE2, there is a substantial difference between the two cohorts. There are numerous advantages. The relationship between PMN cells and other factors, including ascitic fluid PGE2, Hb, WBC, GGT, alkalinity, and MELD score. The relationship between ascitic fluid PGE2 and other WBC is significantly inverse. Conclusion: both blood and ascitic fluid for the detection and eradication of SBP, as well as for predicting death in cirrhotic diseased individuals, PGDE2 and PMN can be employed as diagnostic and prognostic markers","PeriodicalId":22101,"journal":{"name":"Surgery, Gastroenterology and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery, Gastroenterology and Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21614/sgo-514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: One of the most common and dangerous consequences in individuals with decompensated cirrhosis is SBP. Early antibiotic treatment is crucial for effective treatment and lowering death rate. A modulator of the immune response and infection is PGE2. Aim of the Study: To analyze how Prostaglandin E2 and the ascites polymorphic nuclear cell count affect cirrhotic diseased individual mortality prognosis. Material and Methods: Ninety diseased individuals were chosen from the wards of the Internal Medicine Department of Menoufia University Hospitals, the NLI of Menoufia University, and the El Helal Health Insurance Hospital in Shibin Al-Kum for this prospective diagnostic test study. Two cohorts of participants were formed. Cohort I: 45 diseased individuals with hepatic cirrhosis and SBP, as well as 45 diseased individuals without SBP. All diseased individuals had a history review, MELD and CTP scores, a pelvic-abdominal ultrasound, and laboratory investigations such as serum, CBC with differentials made by CRP and ESR, INR and prothrombin time, SAAG, serum creatinine and urea, and liver function tests (ALT and AST), GGT, and Alk.pho. PMN and serum ascitic fluid prostaglandin E2 are included in ascitic fluid analyses. Results: While ascitic fluid PGE2 was elevated in the non-SBP cohort, PMN cell count was elevated in the SBP cohort. Regarding ascitic fluid PGE2, there is a substantial difference between the two cohorts. There are numerous advantages. The relationship between PMN cells and other factors, including ascitic fluid PGE2, Hb, WBC, GGT, alkalinity, and MELD score. The relationship between ascitic fluid PGE2 and other WBC is significantly inverse. Conclusion: both blood and ascitic fluid for the detection and eradication of SBP, as well as for predicting death in cirrhotic diseased individuals, PGDE2 and PMN can be employed as diagnostic and prognostic markers

查看原文本刊更多论文

腹水多态核细胞计数和前列腺素E2在肝硬化患者死亡率中的作用

背景:失代偿性肝硬化患者最常见和最危险的后果之一是收缩压。早期抗生素治疗是有效治疗和降低死亡率的关键。免疫反应和感染的调节剂是PGE2。研究目的:分析前列腺素E2和腹水多态核细胞计数对肝硬化患者死亡率和预后的影响。材料和方法:从Menoufia大学医院内科、Menoufia大学NLI和Shibin Al-Kum的El Helal健康保险医院的病房中选择90名患病个体进行前瞻性诊断试验研究。参与者组成了两组。队列1:45例肝硬化合并收缩压患者，以及45例无收缩压患者。所有患病个体均进行病史回顾、MELD和CTP评分、盆腔腹部超声检查和实验室检查，如血清、CBC (CRP和ESR、INR和凝血酶原时间、SAAG、血清肌酐和尿素)、肝功能检查(ALT和AST)、GGT和Alk.pho。腹水分析包括PMN和血清腹水前列腺素E2。结果:腹水PGE2在非收缩压组中升高，而PMN细胞计数在收缩压组中升高。关于腹水PGE2，两个队列之间存在实质性差异。有很多优点。PMN细胞与腹水PGE2、Hb、WBC、GGT、碱度、MELD评分等因素的关系腹水PGE2与其他WBC呈显著负相关。结论:外周血和腹水PGDE2和PMN均可作为肝硬化患者SBP的诊断和预后指标，用于检测和根除SBP以及预测死亡

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Surgery, Gastroenterology and Oncology Medicine-Gastroenterology

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： Starting with this issue "Annals of Fundeni Hospital", founded in 1996 as the scientific journal of the prestigious hospital Fundeni becomes "Journal of Translational Medicine and Research" (JTMR), an Journal of the Academy of Medical Sciences of Romania. Therefore, an 18 years old Journal, attested and indexed in Elsevier Bibliographic Databases, Amsterdam and also indexed in SCOPUS, is continuing a tradition of excellence that lasted almost two decades. The new title of the Journal is inspired first of all from the important developments of translational research In Fundeni Clinical Institute and the "C.C Iliescu Institute for Cardio-Vascular Diseases", in parallel with the national and international trend to promote and develop this important area or medical research. Although devoted mainly to translational research, JTMR will continue to promote both basic and clinical research.