Serum hepcidin and paraoxonase levels in patients with severe, moderate, and mild obstructive sleep apnea hypopnea syndrome (OSAS): A comparison between OSAS patients and simple snoring patients.

IF 4.8 1区地球科学 Q1 GEOLOGY

Geology Pub Date : 2025-01-01 Epub Date: 2022-05-06 DOI:10.1080/08869634.2022.2070698

Umit Kucuktepe, Omer Tarik Selcuk, Hamit Yasar Ellidag, Dogukan Aydenizoz, Nursel Turkoglu Selcuk, Hulya Eyigor, Levent Renda, Ustun Osma, Mustafa Deniz Yilmaz

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引用次数: 0

Abstract

Objective: To investigate the importance of hepcidin and paraoxonase in obstructive sleep apnea syndrome (OSAS).

Methods: Eighty-eight patients with sleep disorders were included and divided into four groups: simple snoring (SS), mild, moderate, and severe OSAS. All patients underwent polysomnography. The hepcidin and paraoxonase levels were examined and compared between the groups.

Results: There were significant differences between the four groups in terms of paraoxonase levels. In the SS group, the paraoxonase value was significantly higher than in the other three groups. In the analysis, Apnea Hypopnea Index (AHI) was negatively correlated with paraoxonase levels.

Conclusion: A significant difference was found between the OSAS groups with respect to paraoxonase enzyme, and a negative correlation with AHI was observed. Paraoxonase level could be used as a biomarker in OSAS. No significant data was found for hepcidin levels; therefore, hepcidin cannot be used as a biomarker in OSAS.

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重度、中度和轻度阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者的血清血红素和副氧合酶水平：阻塞性睡眠呼吸暂停低通气综合征（OSAS）患者与单纯性打鼾患者的比较。

目的研究促血红素和副氧合酶在阻塞性睡眠呼吸暂停综合征（OSAS）中的重要性：方法：纳入 88 名睡眠障碍患者，将其分为四组：单纯性打鼾（SS）、轻度、中度和重度 OSAS。所有患者均接受了多导睡眠图检查。对各组患者的血红素和副氧酵素水平进行了检查和比较：结果：四组患者的副氧化酶水平存在明显差异。SS组的副氧化酶值明显高于其他三组。在分析中，呼吸暂停低通气指数（AHI）与副氧自由基酶水平呈负相关：结论：副氧自由基酶在 OSAS 各组间存在明显差异，且与 AHI 呈负相关。副氧合酶水平可作为 OSAS 的生物标志物。在血红素水平方面没有发现重要数据，因此血红素不能作为 OSAS 的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geology 地学-地质学

CiteScore

10.00

自引率

3.40%

发文量

228

审稿时长

6.2 months

期刊介绍： Published since 1973, Geology features rapid publication of about 23 refereed short (four-page) papers each month. Articles cover all earth-science disciplines and include new investigations and provocative topics. Professional geologists and university-level students in the earth sciences use this widely read journal to keep up with scientific research trends. The online forum section facilitates author-reader dialog. Includes color and occasional large-format illustrations on oversized loose inserts.