Evaluation of in vitro pharmacological activities of Diospyros malabarica kostel fruit

Sahar Javed, Sabi Rehman, Muzamil Zaman Khan, Anwar Khalid, Rida Qaseem, Muhammad Humayun
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Abstract

Objective: To explore the in vitro pharmacological activities of fruit of Diospyros malabarica. Method: 70% ethanolic extracts of Diospyros malabarica was screened against ten pathogenic bacteria, five strains of gram +ve, five strains of gram –ve bacteria and fungi by using disc diffusion method. Moreover, to study the toxicity of this fruit, we conducted a saltwater shrimp lethality bioassay based on the ability to kill laboratory cultured brine shrimps (Artemiasalina). Results: Fruits extracts were found to exhibit antimicrobial activity against bacterial pathogens with the zone of inhibition ranges between 13mm to 19mm. Fruit Extracts was also tested for its antifungal activity against fungal strains exhibiting zone of inhibition ranges from 14 mm to 19 mm. The fruit extract of Diospyros malabarica shows significant lethality towards brine shrimps at LD50 value of 93.55 ppm. Conclusion: Plant extracts is potentially effective in suppressing microbial and fungal growth. As fruit extracts has significant LD50 value thus it can be further used for cancer cell line studies.
马拉巴利果的体外药理活性评价
目的:探讨马拉巴利果的体外药理活性。方法:采用圆盘扩散法,对马拉巴利木薯蓣70%乙醇提取物进行10种病原菌、5株革兰氏菌、5株革兰氏菌和真菌的抑菌筛选。此外,为了研究该果实的毒性,我们在杀死实验室培养的盐水虾(Artemiasalina)的能力的基础上进行了盐水虾致死生物测定。结果:果实提取物对病原菌具有抑菌活性,抑菌区在13mm ~ 19mm之间。果实提取物对真菌的抑制范围为14 ~ 19 mm。在LD50值为93.55 ppm时,对卤虾具有显著的致死性。结论:植物提取物具有抑制微生物和真菌生长的潜在作用。由于水果提取物具有显著的LD50值,因此可进一步用于癌细胞系研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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