Role of Moringa oleifera leaf extract on silk dye waste effluent inducedhistopathotoxicity on liver and testis of Swiss albino male mice Mus musculus

Abstract

This work focuses primarily on the effects of Moringa oleiferaleaf extract on histopathology of silk dye effluent induced histopathotoxicity in swiss albino male mice Mus musculus. The histopathological parameters have been taken an account. The mice were divided into 5 Groups i.e. Group I (Control), Group II (fed with 50% silk dye), Group III (fed with 100% silk dye), Group IV (mice fed with 50% dye treated with M. oleifera leaves powder), Group V (mice fed with 100% dye treated with M. oleifera leaves powder) have been taken for experiment. The dose of silk dye was 2ml/day to both groups II and III and M. oleifera leaf is given as per the standard dose (300mg/kg b.w) to both animals of group IV and V.Administration of silk dye waste result were demonstrated atrophy of germinal epithelial cells, basement membrane, and process of spermatogenesis in different stage in case of testis and in case of liver, enlargement of the sinusoidal space, vacuole formations in hepatocyte, infiltrations with haemorrhage in hepatic tissuebut used of Moringa oleifera leafs powder it was significantly recovered the damage tissues has been observed. This study suggested that the extract may have beneficial effect on histopathological constituents such as Liver and testis.