Stabilization of labile active ingredients in an oil-water emulsion cosmetics by freeze-drying.

IF 1 4区生物学 Q3 BIOLOGY

Cryo letters Pub Date : 2023-03-01 DOI:10.54680/fr23210110312

Zuxin Yi, Mei Yang, Baolin Liu

引用次数: 0

Abstract

BACKGROUND Due to the instability in oil/water emulsion, certain labile active ingredients were often not used in cosmetics. OBJECTIVE The present study has tested the effect of freeze-drying to stabilize an oil/water cosmetic emulsion. MATERIALS AND METHODS A preliminary freeze-drying process was established at the basis of calorimetric and freeze-drying microscope studies. The stability of labile molecules in the cosmetic emulsion was evaluated at 48 degree C after freeze-drying. RESULTS The accelerated stability experiment showed that the freeze-dried emulsion retained 90.1% vitamin C after 28 days at 48 degree C, whereas the oil-water emulsion retained only 28.3% vitamin C. The freeze-dried emulsion had significantly less oil oxidation than did the oil-water emulsion. CONCLUSION Freeze-drying improved the stability of vitamin C and oily active ingredients in cosmetic emulsions. DOI: 10.54680/fr23210110312.

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冷冻干燥法稳定油水乳液化妆品中不稳定活性成分。

由于油/水乳液的不稳定性，一些不稳定的活性成分在化妆品中经常不被使用。目的研究冷冻干燥对油水化妆品乳状液稳定性的影响。材料与方法在量热法和冷冻干燥显微镜研究的基础上，建立了初步的冷冻干燥工艺。在48℃冷冻干燥后，评价了化妆品乳液中不稳定分子的稳定性。结果加速稳定性实验表明，冻干乳剂经48℃加热28 d后，维生素C的保留率为90.1%，而油水乳剂的保留率仅为28.3%。冻干乳剂的油氧化率明显低于油水乳剂。结论冷冻干燥提高了化妆品乳剂中维生素C和油性有效成分的稳定性。DOI: 10.54680 / fr23210110312。

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来源期刊

Cryo letters 生物-生理学

CiteScore

1.80

自引率

10.00%

发文量

审稿时长

1 months

期刊介绍： A bimonthly international journal for low temperature sciences, including cryobiology, cryopreservation or vitrification of cells and tissues, chemical and physical aspects of freezing and drying, and studies involving ecology of cold environments, and cold adaptation The journal publishes original research reports, authoritative reviews, technical developments and commissioned book reviews of studies of the effects produced by low temperatures on a wide variety of scientific and technical processes, or those involving low temperature techniques in the investigation of physical, chemical, biological and ecological problems.