T-Cell Large Granular Lymphocytic Chronic Leukemia: Treatment Experience with Cyclosporine

Abstract

The patient presented herself at the hospital in June 2018 with severe anemia (Hgb= 5,4g/dl), mild leucopenia (Le= 3980/mm³) and grade III neutropenia (Ne=557/mm³). She underwent bone marrow biopsy and flow cytometry which established the diagnosis of Large Granular T-cell Leukemia. She was given treatment with Ciclosporine 50mg 6cps/day, which was reduced at 3 cps/day because the patient developed pancytopenia at 6cps/day. The blood count test after 6 months of treatment was greatly improved: she obtained normal levels of hemoglobin and platelets, with the persistence of asymptomatic neutropenia. At the one-year follow-up we had an adequate response, but at the 18 months follow-up she has developed mild pancytopenia, which leads us to believe that she is relapsing under the Ciclosporine treatment.