Idarubicin: An Anthracycline For Acute Myelogenous Leukemia

L. Alnaim
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Abstract

Objective: To review the scientific literature evaluating the efficacy and tolerability of Idarubicin, an anthracycline indicated for treatment acute myelogenous leukemia (AML) including French-American-British (FAB) classifications M1 through M7 Data sources: Articles were identified through searches of MEDLINE (1966–April 2007) using the key words idarubicin (IDA), acute myelogenous leukemia, anthracyclines. Additional citations were identified from bibliographies of publications cited. Study selection and data extraction: Experimental and observational studies of IDA were selected. Trials of the efficacy of the drug in humans were the focus of the review. Data synthesis: IDA is an effective alternative for the treatment of different types of AML. It significantly increases complete response rate and survival time when used in combination with other antileukemic drug. In comparative studies, there was a trend toward the superiority of IDA over daunorubicin. However, these data are insufficient to recommend IDA as a replacement for daunorubicin, and further studies will be required to ascertain if statistically significant differences in efficacy exist between the two drugs. Conclusions: Current available clinical trials do not show advantage of one anthracycline over another. However, for APL the combination of all-trans retinoic acid and anthracycline induction therapy represents the mainstay of therapy.
依达柔比星:一种治疗急性骨髓性白血病的蒽环类药物
目的:回顾评价用于治疗急性髓性白血病(AML)的蒽环类药物依达霉素(Idarubicin)疗效和耐受性的科学文献,包括法、美、英(FAB)分类M1至M7。资料来源:通过MEDLINE(1966 - 2007年4月)检索关键词为依达霉素(IDA)、急性髓性白血病、蒽环类药物。从引用的出版物的参考书目中确定了其他引用。研究选择和数据提取:选择IDA的实验研究和观察研究。此次审查的重点是该药物在人体中的疗效试验。数据综合:IDA是治疗不同类型AML的有效替代方案。与其他抗白血病药物联合使用可显著提高完全缓解率和生存时间。在比较研究中,IDA有优于柔红霉素的趋势。然而,这些数据不足以推荐IDA作为柔红霉素的替代品,需要进一步的研究来确定两种药物之间是否存在统计学上的显着差异。结论:目前可用的临床试验并未显示一种蒽环类药物优于另一种。然而,对于APL,全反式维甲酸联合蒽环类诱导治疗是主要的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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