VITILIGO FOKAL PADA ANAK YANG DITERAPI DENGAN TARGET EXCIMER LIGHT 308 NM

Stefani Nurhadi
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Abstract

Vitiligo is a acquired skin disease characterized by a well-defined depigmented macules caused by progressive loss of functional melanocytes. Vitiligo usually appears first during childhood or young adults. Management of vitiligo in children are more difficult because the preference of therapy is limited when compared with adult. Targeted 308 nm UVB phototherapy is used for local vitiligo in children as it can be focused on the lesion and reduce the side effects. A 4-year-old girl, came to dermato-venereology polyclinic of Indera Hospital Denpasar with complaints of white patch on her lips for 3 weeks. Based on the history and physical examination, she was diagnosed with focal vitiligo. She was treated with targeted 308 nm excimer light phototherapy three times a week. Five sessions of phototeraphy resulted good response characterized by repigmentation of the lesion without redness and blisters.The therapy aims to achieve the best results with minimal side effects. Phototherapy targets are recommended for local vitiligo and especially for new small lesions as well as pediatric vitiligo. The mechanisms of this phototherapy is to trigger repigmentation, stabilization, immunosuppression and immunomodulation. The conclusion is targeted 308 nm phototherapy is quite useful for treating vitiligo even though more therapy sessions are needed.
白癜风是一种获得性皮肤病,其特征是由功能性黑色素细胞的逐渐丧失引起的明确的脱色斑。白癜风通常首先出现在儿童或青年时期。与成人相比,儿童白癜风的治疗更困难,因为对治疗的偏好有限。靶向308 nm UVB光疗用于治疗儿童局部白癜风,因为它可以聚焦病灶,减少副作用。一名4岁女孩,因嘴唇出现白斑3周,来到登巴萨因德拉医院皮肤性病综合诊所就诊。根据病史和体格检查,诊断为局灶性白癜风。她接受靶向308 nm准分子光治疗,每周3次。五个疗程的摄影效果很好,其特征是病变重新着色,无红肿和水泡。该疗法旨在以最小的副作用达到最佳效果。光疗目标推荐用于局部白癜风,特别是对于新的小病变以及儿科白癜风。这种光疗的机制是触发色素沉着、稳定、免疫抑制和免疫调节。结论是308 nm定向光疗对白癜风的治疗是非常有用的,即使需要更多的治疗疗程。
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