Association of Substance Abuse, Violence, HIV/AIDS (SAVA) Syndrome with STI and HIV-Infection Among Injecting Drug Users in Six Cities of Russian Federation

IF 2.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina-Lithuania Pub Date : 2021-01-01 DOI:10.29234/2308-9113-2021-9-2-48-62

A. N. Barinova, A. Lebedeva, N. Ladnaya, B. Tayts, E. Zaytseva, O. Leonova, S. L. Plavinskii

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引用次数: 0

Abstract

Introduction. Described at the beginning of HIV epidemics in the USA syndrome (or syndemia) of substance abuse, violence and AIDS (SAVA) still continue to be an important risk factor for HIV-infection acquisition. The goal of this study was to analyze association between SAVA and STI and also new cases of HIV infection among IDU in six cities in Russian Federation. Materials and methods. Analysis is based on the data from bio-behavioral survey conducted in six Russian cities with help of respondent-driven sampling. Results. It was found no statistically significant association between SAVA and STI after correction for sampling, but without correction STI prevalence in group without SAVA was 4.1% and in group with SAVA and binge drinking – 9,2% (р=0.04). Stratified analysis showed that it is impossible to combine data from males and females and in case of separate analysis statistically significant association between SAVA and STI exists in females (р=0,027). Analysis with adjustment for interview site, gender and age SAVA with binge drinking significantly elevates STI risk (OR=2.69 [95%CI=1.21... 5.99], р=0.016). Study of association between SAVA components and new cases of HIV found that experience of physical and/or sexual violence combined with binge drinking increase risk of HIV acquisition (adjusted for interview site, gender, age, needle/syringe sharing, education and sex work OR=4.03 [95%CI=1.19...13.69], р=0.026). Experience of physical and/or sexual violence combined with binge drinking was significantly associated with such HIV risk factors as needle and syringe sharing (OR=3.07 [95%CI=1.02...9.24], p=0.046) and sex work (OR=17.29 [95%CI=3.83...77.96], p<0.001). Conclusion. SAVA existence should be taken into account when planning preventive measures in Russian Federation and existing programs of comprehensive prevention should have components designed to decrease consequences of syndemia.

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俄罗斯联邦六个城市注射吸毒者中药物滥用、暴力、艾滋病毒/艾滋病(SAVA)综合征与性传播感染和艾滋病毒感染的关联

介绍。在美国艾滋病毒流行之初所描述的药物滥用、暴力和艾滋病综合症(或综合症)仍然是艾滋病毒感染的一个重要危险因素。本研究的目的是分析俄罗斯联邦六个城市的性传播感染和性传播感染之间的关系以及注射吸毒者中艾滋病毒感染的新病例。材料和方法。分析基于在俄罗斯六个城市进行的生物行为调查的数据，并借助受访者驱动的抽样。结果。经抽样校正后，发现SAVA与STI之间无统计学意义的相关性，但未经校正，未SAVA组的STI患病率为4.1%，SAVA和酗酒组的STI患病率为9.2% (χ =0.04)。分层分析显示，不可能将男性和女性的数据结合起来，在单独分析的情况下，女性的SAVA和STI之间存在统计学上显著的关联(χ = 0.027)。对访谈地点、性别和年龄进行调整后的分析显示，酗酒的SAVA显著增加了性传播感染的风险(OR=2.69 [95%CI=1.21…]5.99],р= 0.016)。SAVA组成部分与艾滋病新发病例之间的关联研究发现，经历身体和/或性暴力并合并酗酒会增加感染艾滋病毒的风险(根据访谈地点、性别、年龄、共用针头/注射器、教育程度和性工作进行调整or =4.03 [95%CI=1.19…13.69]，r =0.026)。经历身体暴力和/或性暴力并酗酒与共用针头和注射器(or =3.07 [95%CI=1.02…9.24]，p=0.046)和性工作(or =17.29 [95%CI=3.83…77.96]，p<0.001)等艾滋病毒危险因素显著相关。结论。在俄罗斯联邦规划预防措施时应考虑到是否存在SAVA，现有的综合预防方案应包含旨在减少综合征后果的组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina-Lithuania 医学-医学：内科

CiteScore

3.30

自引率

3.80%

发文量

1578

审稿时长

25.04 days

期刊介绍： The journal’s main focus is on reviews as well as clinical and experimental investigations. The journal aims to advance knowledge related to problems in medicine in developing countries as well as developed economies, to disseminate research on global health, and to promote and foster prevention and treatment of diseases worldwide. MEDICINA publications cater to clinicians, diagnosticians and researchers, and serve as a forum to discuss the current status of health-related matters and their impact on a global and local scale.