Cytotoxic effect of hydroalcoholic extract of Cota tinctoria (L.) J.Gay on AGS and Hep-G2 cancer cell lines

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-01 DOI:10.37360/blacpma.22.21.1.07

Sharareh Shamloo, Sayeh Jafari Marandi, G. Tajadod, A. Majd, R. Rahimi

引用次数: 2

Abstract

Cota tinctoria is a medicinal plant which has been used for management of cancer in folk medicine of various regions. The aim of present study is to investigate cytotoxic activity of different concentrations of hydroalcoholic extract of C. tinctoria flowers on gastric (AGS) and liver (Hep-G2) cancer cell lines as well as Human Natural GUM fibroblast (HUGU) cells. Cell mortality rates were examined after 24, 48 and 72 h incubations using the MTT assay. IC50 of extract on AGS cells after 24, 48 and 72h was 1.46, 1.29 and 1.14 µg/mL respectively. The extract demonstrated IC50 of 5.15, 3.92 and 2.89 µg/mL on Hep-G2 cells after 24, 48 and 72 h respectively. No cytotoxic effect was detected on HUGU (Human Natural GUM fibroblast) cells. C. tinctoria seems to have a promising potential to be considered as a source for anticancer drug discovery. However, more experimental and clinical studies are required.

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花楸水醇提取物的细胞毒作用J.Gay对AGS和Hep-G2癌细胞系的研究

鸢尾草是一种药用植物，在各地民间医学中被用于治疗癌症。本研究旨在探讨不同浓度的金花水醇提取物对胃癌(AGS)和肝癌(Hep-G2)细胞系以及人天然胶质成纤维细胞(HUGU)的细胞毒活性。用MTT法检测孵育24、48和72 h后的细胞死亡率。提取液对AGS细胞作用24、48、72h后的IC50分别为1.46、1.29、1.14µg/mL。对Hep-G2细胞作用24、48、72 h的IC50分别为5.15、3.92、2.89µg/mL。对人天然胶质成纤维细胞(HUGU)无细胞毒作用。C. tinctoria似乎有很大的潜力被认为是抗癌药物发现的一个来源。然而，还需要更多的实验和临床研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.