An Integrated Cross-Database Search System for microRNA

Abstract

MicroRNAs (miRNAs) are small noncoding RNA gene products. It is important in biology and biomedicine. The miRNA is closely related to human disease, in particular, such as cancer and tumor. We develop an information system for miRNA, which integrates a variety of existing miRNA information system on the market. The system offers as much information as possible; meanwhile it costs as less time as possible by using simultaneous processing technologies, and reduces information redundancy by knowledge discover mechanisms. A special mechanism is used to speed up the query. We collect miRNA links from existing key systems through search engine and obtain all miRNA information by these links. Then after removing noise and irrelevant ones, we extract and separate the useful information from them. After that, we synthesize and compose comprehensive information in accordance with the cache database. Finally, an effective and efficient integrated cross-database miRNA query system, as well as user friendly GUI, is provided. Key Words—bioinformatics, microRNA, miRNA, web service, query system