{"title":"\"Does Inhaled Corticosteroids Increase the Risk of Nontuberculous Mycobacteria Pulmonary Disease: A Meta-Analysis\"","authors":"Jianfeng Li","doi":"10.26717/bjstr.2021.39.006363","DOIUrl":null,"url":null,"abstract":"Li. Does Inhaled Corticosteroids Increase the Risk of Nontuberculous Mycobacteria Pulmonary Disease: A Meta-Analysis. Biomed of NTM-PD with the usage of ICS among chronic respiratory patients. Methods: The PubMed, EMBASE and Web of Science databases were applied to identify eligible studies until Nov. 18, 2019. Studies focusing on the correlation between ICS and NTM-PD among chronic respiratory patients were concluded. Odds Ratio (ORs) with 95% confidence intervals (95% CIs) were extracted and synthesized to evaluate the risk of NTM-PD with the usage of ICS. Heterogeneity was assessed by using Cochran Q and I-square statistics. Sensitivity and subgroup analysis were performed to trace the source of heterogeneity. Results: A total of 5 studies with 20968 chronic respiratory patients were enrolled in current meta-analysis. The pooled OR for the risk of NTM-PD with the usage of ICS was 1.97 (95% CI: 1.45—2.67, I2=77.3%, P=0.001). In sensitivity analysis, Bual’s study was the origin of heterogeneity. In the subgroup analysis, there was a trend towards the increased risk of NTM-PD with the usage of ICS among asthma and COPD patients. In addition, high-dose and current usage of ICS could increase the risk of NTM-PD. A positive relationship was the of ICS and the risk of NTM-PD. In the future, the selection of ICS should be more cautious.","PeriodicalId":9035,"journal":{"name":"Biomedical Journal of Scientific & Technical Research","volume":"60 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical Journal of Scientific & Technical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26717/bjstr.2021.39.006363","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Li. Does Inhaled Corticosteroids Increase the Risk of Nontuberculous Mycobacteria Pulmonary Disease: A Meta-Analysis. Biomed of NTM-PD with the usage of ICS among chronic respiratory patients. Methods: The PubMed, EMBASE and Web of Science databases were applied to identify eligible studies until Nov. 18, 2019. Studies focusing on the correlation between ICS and NTM-PD among chronic respiratory patients were concluded. Odds Ratio (ORs) with 95% confidence intervals (95% CIs) were extracted and synthesized to evaluate the risk of NTM-PD with the usage of ICS. Heterogeneity was assessed by using Cochran Q and I-square statistics. Sensitivity and subgroup analysis were performed to trace the source of heterogeneity. Results: A total of 5 studies with 20968 chronic respiratory patients were enrolled in current meta-analysis. The pooled OR for the risk of NTM-PD with the usage of ICS was 1.97 (95% CI: 1.45—2.67, I2=77.3%, P=0.001). In sensitivity analysis, Bual’s study was the origin of heterogeneity. In the subgroup analysis, there was a trend towards the increased risk of NTM-PD with the usage of ICS among asthma and COPD patients. In addition, high-dose and current usage of ICS could increase the risk of NTM-PD. A positive relationship was the of ICS and the risk of NTM-PD. In the future, the selection of ICS should be more cautious.