"Does Inhaled Corticosteroids Increase the Risk of Nontuberculous Mycobacteria Pulmonary Disease: A Meta-Analysis"

Abstract

Li. Does Inhaled Corticosteroids Increase the Risk of Nontuberculous Mycobacteria Pulmonary Disease: A Meta-Analysis. Biomed of NTM-PD with the usage of ICS among chronic respiratory patients. Methods: The PubMed, EMBASE and Web of Science databases were applied to identify eligible studies until Nov. 18, 2019. Studies focusing on the correlation between ICS and NTM-PD among chronic respiratory patients were concluded. Odds Ratio (ORs) with 95% confidence intervals (95% CIs) were extracted and synthesized to evaluate the risk of NTM-PD with the usage of ICS. Heterogeneity was assessed by using Cochran Q and I-square statistics. Sensitivity and subgroup analysis were performed to trace the source of heterogeneity. Results: A total of 5 studies with 20968 chronic respiratory patients were enrolled in current meta-analysis. The pooled OR for the risk of NTM-PD with the usage of ICS was 1.97 (95% CI: 1.45—2.67, I2=77.3%, P=0.001). In sensitivity analysis, Bual’s study was the origin of heterogeneity. In the subgroup analysis, there was a trend towards the increased risk of NTM-PD with the usage of ICS among asthma and COPD patients. In addition, high-dose and current usage of ICS could increase the risk of NTM-PD. A positive relationship was the of ICS and the risk of NTM-PD. In the future, the selection of ICS should be more cautious.