Identification of Biomarkers in an Oral Malignant Melanoma Case with Potential for Therapeutic Intervention

R. Pai, S. Pai, R. Lalitha, S. Kumaraswamy, N. Lalitha, R. Johnston, M. Bhargava
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Abstract

A 32-year old female patient presented with the tumor of the oral cavity at the Kidwai Memorial Institute of Oncology, Bangalore, India. Clinical examination and histopathological analyses confirmed the neoplasm as malignant melanoma. This rare melanoma of the buccal mucosa expressed carcinoembryonic antigen (CEA) as well as contained cells that expressed elevated levels of the c-myc oncogene product as identified by immunohistochemistry of the tumor biopsy. Presence of these tumor makers in the rare case of malignant melanoma with poor prognosis should allow exploration of novel targeted therapy against CEA and c-Myc.
口腔恶性黑色素瘤病例中生物标志物的鉴定及其治疗干预的潜力
一位32岁的女性患者在印度班加罗尔的Kidwai肿瘤纪念研究所提出了口腔肿瘤。临床检查和组织病理学分析证实该肿瘤为恶性黑色素瘤。这种罕见的颊粘膜黑色素瘤表达癌胚抗原(CEA),并且包含表达升高水平的c-myc癌基因产物的细胞,通过肿瘤活检的免疫组织化学鉴定。在罕见的预后不良的恶性黑色素瘤病例中,这些肿瘤制造者的存在应该允许探索针对CEA和c-Myc的新型靶向治疗。
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