The Role of Cytokines in Inflammatory Process of Knee Osteoarthritis: Systematic Review

Florencia Christofora Ngantung, B. Supartono, Hikmah Muktamiroh
{"title":"The Role of Cytokines in Inflammatory Process of Knee Osteoarthritis: Systematic Review","authors":"Florencia Christofora Ngantung, B. Supartono, Hikmah Muktamiroh","doi":"10.30742/jikw.v11i2.2444","DOIUrl":null,"url":null,"abstract":"Osteoarthritis (OA) is a degenerative joint disorder that occurs in cartilage. OA is the main cause of disability in adults and generally characterized by pain to the joints that got pressured. Based on several previous studies, it is known that the incidence of osteoarthritis is correlated with synovial inflammation and that inflammatory cytokines play an important role in the expansion of osteoarthritis. Based on these things, the author intends to conduct a literature study with the aim of knowing the role of cytokines on inflammation in knee osteoarthritis. The research was conducted through PubMed and Science Direct databases. The results of the study showed that cytokines played negative different roles depending on the type of cytokines such as those found in knee OA inflammation. Conclusion: Cytokines have a negative effect because they can disrupt synovial tissue balance, induce catabolic processes, and induce osteoclast differentiation and subchondral bone resorption.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"24 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30742/jikw.v11i2.2444","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Osteoarthritis (OA) is a degenerative joint disorder that occurs in cartilage. OA is the main cause of disability in adults and generally characterized by pain to the joints that got pressured. Based on several previous studies, it is known that the incidence of osteoarthritis is correlated with synovial inflammation and that inflammatory cytokines play an important role in the expansion of osteoarthritis. Based on these things, the author intends to conduct a literature study with the aim of knowing the role of cytokines on inflammation in knee osteoarthritis. The research was conducted through PubMed and Science Direct databases. The results of the study showed that cytokines played negative different roles depending on the type of cytokines such as those found in knee OA inflammation. Conclusion: Cytokines have a negative effect because they can disrupt synovial tissue balance, induce catabolic processes, and induce osteoclast differentiation and subchondral bone resorption.
细胞因子在膝关节骨关节炎炎症过程中的作用:系统综述
骨关节炎(OA)是一种发生在软骨中的退行性关节疾病。骨性关节炎是成人致残的主要原因,通常以关节受压疼痛为特征。基于以往的多项研究,我们知道骨关节炎的发病率与滑膜炎症相关,炎症因子在骨关节炎的扩张中起着重要作用。在此基础上,笔者拟进行文献研究,了解细胞因子在膝关节骨关节炎炎症中的作用。该研究通过PubMed和Science Direct数据库进行。研究结果显示,不同类型的细胞因子(如在膝关节OA炎症中发现的细胞因子)发挥了不同的负作用。结论:细胞因子可破坏滑膜组织平衡,诱导分解代谢过程,诱导破骨细胞分化和软骨下骨吸收。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
13
审稿时长
6 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信