A facile synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates

International Journal of Chemical and Analytical Science Pub Date : 2013-09-01 DOI:10.1016/j.ijcas.2013.07.008

Kishore Kumar Anantoju , Giri Tharikoppula , Laxminarayana Eppakayala , Thirumala Chary Maringanti

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Abstract

Objective

To develop an efficient method for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates which is suitable for different naphthyridines.

Methods

All reagents used were commercial grade, ¹H NMR spectra were obtained on a varian 400 MHz instrument with TMS as internal standard and chemical shifts are expressed δ ppm solvent used in DMSO-d₆ & CDCl₃ and LC–MS spectrum on a Waters LC–MS spectrometer operating at 70 ev. TLC is performed with E-Merch precoated silica gel plates (60F-254) with iodine as a developing agent. Acme, India silica gel, 60–120 mesh for column chromatography is used. All compounds are purified by column chromatography by using Silica gel (60–120 mesh) eluted with (50:1) dichloromethane in methanol.

Conclusions

We have developed an efficient protocol for the synthesis of Methyl-2-(N-ethyl-N-phenylamino)naphthyridine-3-carboxylates.

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甲基-2-(n -乙基- n -苯胺)萘啶-3-羧酸酯的简单合成

目的建立一种适用于不同萘啶的甲基-2-(n -乙基- n -苯胺)萘啶-3-羧酸盐的高效合成方法。方法所用试剂均为商品级，在瓦里安400 MHz仪器上以TMS为内标获得1H NMR谱，化学位移用δ ppm表示，溶剂DMSO-d6 &CDCl3和LC-MS光谱在Waters LC-MS光谱仪上工作在70 ev。薄层色谱采用E-Merch预涂硅胶板(60F-254)，碘作为显影剂。Acme，印度硅胶，60-120目用于柱层析。所有化合物通过柱层析纯化，使用硅胶(60-120目)用甲醇中(50:1)的二氯甲烷洗脱。结论建立了一种合成甲基-2-(n -乙基- n -苯基氨基)萘啶-3-羧酸盐的高效方法。

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International Journal of Chemical and Analytical Science

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