Transcription factor ZBTB20: What expression is telling us of its cellular function?

Abstract

Transcription factors are key regulators of cell fate maintenance and transition. Thus, they represent key molecular targets in the fields of stem cell biology and regenerative medicine. The constant need to generate protocols with higher stem cell yield, faster and more efficient differentiation led to in-depth understanding of the function of many transcription factors in regulating developmental and adult stem cells. In this Dance Round we summarize the current understanding of the expression of a zinc finger and BTB domain-containing transcription factor ZBTB20, and comment on how its expression provides clues for its involvement in stem cell biology. Biomed Rev 2020; 31: 1-10