Association between selected immune markers and low ankle-brachial index in virologically suppressed HIV-infected patients on antiretroviral therapy in Nigeria

IF 0.3 Q4 INFECTIOUS DISEASES
C. Agu, I. Uchendu, C. Okwuosa, P. Achukwu
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Abstract

Introduction: People living with human immunodeficiency virus (HIV) on effective antiretroviral treatment (ART) are exposed to an increased risk of cardiovascular disease, often linked to inflammation and immune activation. Ankle-brachial index (ABI) has been widely accepted as screening tool for peripheral arterial disease (PAD) and future cardiovascular events, and is inexpensive and noninvasive compared to carotid intima-media thickness measurements. This study aimed at determining the association between low ankle-brachial index and selected immune markers among virologically suppressed HIV-infected participants on ART in Kwara State, Nigeria. Material and methods: This analytical cross-sectional study was conducted between July 2018 and December 2018. One hundred and fifty HIV-infected participants and fifty HIV non-infected age matched controls were recruited into the study. Ankle-brachial index was measured, and peripheral arterial disease was defined as ABI of < 0.9. Cryopreserved plasma was used to evaluate interleukin (IL)-6 and sCD14. Student’s t-test and c2 test were used to compare continuous and categorical variables. Associations of CVD and immunologic markers with low ABI were assessed using logistic regression analysis. Results: The study group had significantly lower mean values for ABI and significantly higher mean values of IL-6 and sCD14 compared to the control group (p < 0.05). The prevalence of low ABI (14.6%) was higher in the study group compared to the control group (2%). IL-6 (OR 0.992, p = 0.087) and sCD14 (OR 0.918, p = 0.058) were not associated with low ABI in the study group. Conclusions: HIV-infected individuals on suppressive ART demonstrate increased levels of IL-6 and sCD14 compared to not infected controls. The impact of inflammation and immune activation on PAD in treated HIV-infection requires further investigation. HIV AIDS Rev 2020; 19, 4: 227-236 DOI: https://doi.org/10.5114/hivar.2020.101502
尼日利亚接受抗逆转录病毒治疗的病毒学抑制hiv感染患者中选定的免疫标记物与低踝臂指数之间的关系
导读:接受有效抗逆转录病毒治疗(ART)的人类免疫缺陷病毒(HIV)感染者患心血管疾病的风险增加,通常与炎症和免疫激活有关。踝肱指数(ABI)已被广泛接受为外周动脉疾病(PAD)和未来心血管事件的筛查工具,与颈动脉内膜-中膜厚度测量相比,它便宜且无创伤。本研究旨在确定在尼日利亚Kwara州接受抗逆转录病毒治疗的病毒学抑制的hiv感染参与者中,低踝臂指数和选定的免疫标记物之间的关系。材料和方法:本分析性横断面研究于2018年7月至2018年12月进行。150名艾滋病毒感染者和50名年龄匹配的未感染艾滋病毒的对照组被招募到这项研究中。测量踝肱指数,ABI < 0.9为外周动脉病变。冻存血浆检测白细胞介素(IL)-6和sCD14。使用学生t检验和c2检验比较连续变量和分类变量。采用logistic回归分析评估心血管疾病和免疫标志物与低ABI之间的关系。结果:研究组ABI均值显著低于对照组,IL-6、sCD14均值显著高于对照组(p < 0.05)。研究组的低ABI患病率(14.6%)高于对照组(2%)。研究组IL-6 (OR 0.992, p = 0.087)和sCD14 (OR 0.918, p = 0.058)与低ABI无相关性。结论:与未感染的对照组相比,接受抑制性抗逆转录病毒治疗的hiv感染者IL-6和sCD14水平升高。在治疗的hiv感染中,炎症和免疫激活对PAD的影响需要进一步研究。艾滋病Rev 2020;[j] .中南大学学报(自然科学版),2016,34 (4):227-236 DOI: https://doi.org/10.5114/hivar.2020.101502
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来源期刊
HIV & AIDS Review
HIV & AIDS Review INFECTIOUS DISEASES-
CiteScore
0.50
自引率
0.00%
发文量
30
审稿时长
12 weeks
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