The obesity impact on fertility

Abstract

New studies describe that the microenvironment in uterus defines the obesity of the future new born1 affecting in a higher proportion males.2 Animal models, 3,4 have demonstrated the expression and suppression of genes associated to the mother’s diet that affect the placental microenvironment5 and promotes obesity. These state correlates with chronic low-grade inflammation6,7 and immune system activation accompanied by insulin resistance.8 On the long run, there is a long (intra uterus-pre-puberty-puberty-post puberty),9 proinflammatory environment on germ cells. Childhood and puberty