Features of lipid and electrolyte metabolism indicators, NT-pro BNP level in patients with heart failure and atrial fibrillation

Abstract

Resume. The relevance of the problem of chronic heart failure (CHF) for doctors in many countries remains in the leading positions and is due to the prevalence of the pathology and significant economic losses - the severity of the course of the disease, the need for hospitalization and a significant level of mortality.The purpose. To study indicators of lipid and electrolyte metabolism, the level of NT-pro BNP in patients with heart failure and atrial fibrillation.Material and methods. 100 patients aged 45-65 were examined. All patients were divided into groups: Group I – patients with HF with sinus rhythm or atrial fibrillation (AF) (permanent or persistent form), (n=50). II group - patients without HF with AF, (n=50). III – control group: 36 practically healthy people. All patients underwent a clinical examination, blood lipid profile, determination of NT-proBNP level by immunoenzymatic method, ECG, echocardiography (ECHOKG).Research results. The analysis of the lipid profile of the examined patients indicates a violation of lipid metabolism, the development of dyslipidemia, which is an important risk factor and progression of coronary heart disease (CHD). The results of electrolyte exchange indicate the existence of significant differences in the levels of K+, Mg2+ Na+ in the blood serum of healthy and CHF patients. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF in comparison with healthy ones. In addition, the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. Indicators of NT-pro BNP level in patients with CHF and AF were significantly higher (p<0.05) than similar parameters in patients without CHF with AF.Conclusions. Violations of the lipid spectrum of the blood were detected, which indicates the progression of coronary heart disease and is a predictor of an unfavorable prognosis in patients with chronic heart failure. There was a probable difference in the direction of a decrease in the levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF compared to healthy people. Levels of K+, Mg2+ Na+ in the blood serum of patients with CHF and AF were probably lower than in patients with CHF with sinus rhythm. An increase in the level of NT-proBNP was found in patients with HF and AF compared to patients with HF and sinus rhythm.