Assessment of Coagulation and Haematological Parameters among Pregnant Women in Port Harcourt

International Blood Research & Reviews Pub Date : 2022-01-05 DOI:10.9734/ibrr/2022/v13i130165

B. Echonwere-uwikor, F. K. Uwikor, O. Chukuigwe-Igbere, P. H. Chukwu, Gift Worlu

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Abstract

Background: Pregnancy is the fertilization and development of an embryo or fetus in a woman's uterus. It is a critical stage of development during which maternal nutrition can strongly influence obstetric and neonatal outcomes. The aim of this study was to determine the effect of pregnancy on some coagulation and haematological parameters of pregnant women residing in Port Harcourt, Nigeria. Method: This case-control study investigated 80 pregnant subjects and 20 non-pregnant controls. Haematological parameters were determined using a fully automated The SysmexXP-300, while the coagulation parameters (PT and INR) were determined with the automated method. Results: The mean PT (s), HB (g/dl), PCV (%), PLT (x109/L), RBC (mcL), LYMPH (%), BASO (%) and EOSIN (%) counts were significantly lower among the pregnant subjects (5.02±5.82, 11.00±1.13 g/dl and 33.81±3.89%, 189.6±52.93 × 109/L, 3.95±0.50, 43.93±10.10 %, 0.9385±1.08 % and 1.12±1.32 %) compared to the non-pregnant controls (1.68±2.37, 12.01±1.29 g/dl, 37.31±3.39 %, 235.6±72.37 × 109/L, 4.45±0.35, 43.24±9.06, 2.11±0.94 and 2.15±1.47) respectively. There were no significant differences in the INR, MONO (%), MPV (fl), MCV (L/C), and MCH (g/c) between the pregnant subjects (0.92±0.11, 5.41±2.59 %, 11.67±4.848, 84.26±3.77 and 28.06±3.54) and non-pregnant controls (0.88±0.11, 5.58±2.65, 11.14±5.45, 82.52±10.45 and 26.96±1.85). The NEUT (%), PDW (%) and WBC (x109/L) were significantly higher among the pregnant subjects (44.90±11.24 %, 13.26±2.56 % and 8.35±2.982 x109/L) compared to the non-pregnant controls (46.63±9.96 %, 10.78±1.80 % and 4.71±0.81 x109/L). Conclusion: This study has shown that pregnancy has a significant effect on some haematological and coagulation parameters of pregnant women in Port Harcourt. The result of this research work indicates the need to routinely monitor the complete blood count, thrombocytopenia and hyper-coagulative activity among pregnant women of African descendant.

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哈科特港孕妇凝血和血液学指标的评估

背景:怀孕是胚胎或胎儿在女性子宫内受精和发育的过程。这是发育的一个关键阶段，在此期间，产妇营养对产科和新生儿结局有很大影响。本研究的目的是确定怀孕对居住在尼日利亚哈科特港的孕妇的一些凝血和血液学参数的影响。方法:采用病例-对照研究，对80例孕妇和20例非孕妇进行调查。血液学参数采用全自动SysmexXP-300测定，凝血参数(PT和INR)采用自动化方法测定。结果:妊娠组PT (s)、HB (g/dl)、PCV(%)、PLT (x109/L)、RBC (mcL)、LYMPH(%)、BASO(%)、EOSIN(%)的平均值分别为5.02±5.82、11.00±1.13 g/dl和33.81±3.89%、189.6±52.93 × 109/L、3.95±0.50、43.93±10.10%、0.9385±1.08%和1.12±1.32%，显著低于未妊娠组(1.68±2.37、12.01±1.29 g/dl、37.31±3.39%、235.6±72.37 × 109/L、4.45±0.35、43.24±9.06、2.11±0.94和2.15±1.47)。妊娠组的INR、MONO(%)、MPV (fl)、MCV (L/C)、MCH (g/ C)在妊娠组(0.92±0.11、5.41±2.59 %、11.67±4.848、84.26±3.77、28.06±3.54)与未妊娠组(0.88±0.11、5.58±2.65、11.14±5.45、82.52±10.45、26.96±1.85)之间无显著差异。妊娠组NEUT(%)、PDW(%)和WBC (x109/L)分别为44.90±11.24%、13.26±2.56%和8.35±2.982 x109/L，显著高于未妊娠组(46.63±9.96%、10.78±1.80%和4.71±0.81 x109/L)。结论:本研究表明，妊娠对哈科特港孕妇的一些血液学和凝血参数有显著影响。本研究结果提示非洲裔孕妇需要常规监测全血细胞计数、血小板减少症和高凝血活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Blood Research & Reviews

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