Clinical epidemiology and disease burden of adenoviral encephalitis in hospitalized children in China: A nationwide cross-sectional study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-08-25 eCollection Date: 2023-12-01 DOI:10.1002/ped4.12396

Jiao Tian, Xinyu Wang, Linlin Zhang, Qi Li, Guoshuang Feng, Yueping Zeng, Ran Wang, Zhengde Xie

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引用次数: 0

Abstract

Importance: Adenovirus encephalitis is a significant infectious disease of the central nervous system that commonly affects children under the age of 5 and has a profound impact on the health of infants and young children throughout China. National multicenter epidemiological studies have significant public health implications.

Objective: This study aims to report the epidemiology of adenovirus encephalitis in hospitalized children in China, providing valuable guidance for clinicians.

Methods: The data utilized in this study were extracted from the comprehensive Futang Update Medical Records database, which comprises discharge medical records collected by 27 tertiary children's hospitals between January 2016 and December 2018 in China. Specifically, the face sheet of discharge medical records encompassed critical sociodemographic variables and basic medical care details.

Results: In this database, a total of 544 children were hospitalized due to adenoviral encephalitis. The male-to-female ratio was 1.62:1, with more boys being affected across different age groups and places of residence. Of the children hospitalized, the highest number of hospitalizations occurred in the 1-3-year age group and the number of hospitalizations decreased each year from 2016 to 2018. The disease exhibits seasonal characteristics with a pronounced peak in the summer months of June and July. While most children (58%) did not have any significant complications, one-third of them developed respiratory complications, including pneumonia and acute bronchitis. The median length of stay for adenoviral encephalitis was 7 days, and the median cost of hospitalization was 2145.56 US dollars.

Interpretation: This study highlights the prevalence of adenovirus encephalitis in hospitalized children in China. Children aged 1-3 years were found to be the main demographic hospitalized due to this condition, with boys being significantly more affected than girls. The seasonal variations of adenovirus encephalitis were also found to be significant. Fortunately, the fatality rate associated with this condition was low, and the prognosis was generally favorable.

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中国住院儿童腺病毒性脑炎的临床流行病学和疾病负担:一项全国性的横断面研究。

重要性:腺病毒脑炎是一种重要的中枢神经系统感染性疾病，常见于5岁以下儿童，对中国婴幼儿健康有着深远的影响。国家多中心流行病学研究具有重要的公共卫生意义。目的:报道中国住院儿童腺病毒脑炎的流行病学，为临床医生提供有价值的指导。方法:本研究使用的数据提取自福堂更新病历综合数据库，该数据库包含2016年1月至2018年12月全国27家三级儿童医院的出院病历。具体来说，出院病历的人脸表包含了关键的社会人口变量和基本的医疗细节。结果:在本数据库中，共有544名儿童因腺病毒性脑炎住院。男女比例为1.62:1，不同年龄组和居住地的男孩受影响较多。在住院儿童中，住院人数最多的是1-3岁年龄组，2016 - 2018年住院人数逐年下降。该病具有季节性特征，夏季6、7月发病高峰明显。虽然大多数儿童(58%)没有任何明显的并发症，但其中三分之一出现呼吸道并发症，包括肺炎和急性支气管炎。腺病毒性脑炎的住院时间中位数为7天，住院费用中位数为2145.56美元。解释:本研究强调了中国住院儿童中腺病毒脑炎的患病率。发现1-3岁儿童是因这种情况住院的主要人口，男孩比女孩受影响明显更大。腺病毒脑炎的季节变化也很显著。幸运的是，与这种情况相关的死亡率很低，预后一般良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.