EPR and FTIR Spectroscopies Study of Human Blood after Irradiation

M. Polakovs, Ņ. Mironova-Ulmane, A. Pavlenko, E. Reinholds, M. Gavare, M. Grube, P. Stradins
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引用次数: 6

Abstract

In the present work we report results of investigations of human blood before and after radioisotope Tc 99m diagnosis by electron paramagnetic resonance (EPR) and Fourier transform infrared (FTIR) spectroscopies. It is shown that EPR can detect the concentration of methaemoglobin and transferrin ions more accurately than any other technique. FTIR spectra indicated that radiation caused conformational and concentration changes of proteins. Hierarchical cluster analysis (HCA) was created as time-saving tool for discrimination of initial and irradiated in vivo human blood samples.
辐照后人体血液的EPR和FTIR光谱研究
在本工作中,我们报告了用电子顺磁共振(EPR)和傅里叶变换红外(FTIR)光谱对放射性同位素Tc 99m诊断前后人体血液的调查结果。结果表明,EPR能比其他方法更准确地检测出血红蛋白和转铁蛋白的浓度。红外光谱显示,辐射引起蛋白质构象和浓度的变化。建立了层次聚类分析(HCA)作为一种省时的工具来区分初始和辐照的人体内血液样本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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