Comparative Hypoglycemic Effects of Cassia Glauca Lam. in Streptozotocin- Induced Diabetic Rats

Abstract

The aim of this study was to evaluate comparative hypoglycemic activity of aqueous extract of Cassia glauca leaf and bark. The various parameters studied included effect on fasting blood glucose levels of normoglycemic rats, oral glucose tolerance test and hypoglycemic activity in streptozotocin induced diabetic rats. On oral administration , aqueous extract showed statistically significant (P < 0.001) effect by reducing the effect of external glucose load in diabetic rats. In chronic model of treatment, the difference between the experimental (Cassia glauca bark extract) rats in lowering the fasting plasma glucose levels was statistically significant (P < 0.001) as compared in diabetic rats on day 21. These findings suggest the significant hypoglycemic potential of the Cassia glauca bark extracts in ameliorating the diabetic conditions in diabetic rats. No significant effects were found in the normal rats. Source of Support: The authors sincerely thank Dr. F. V. Manvi, Principal, KLES’s College of Pharmacy for providing the necessary facilities for this work.