Synthesis and molecular docking studies on biologically active N-((3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl) methylene)aniline derivatives

Abstract

Heterocycles are well known for displaying a wide range of biological properties (Monica Arora et al., 2013). The structural diversity and biological importance of nitrogen containing heterocycles have made them attractive synthetic targets over many years (Azam et al., 2007). In general, well-known five–membered heterocyclic compounds are oxadiazoline, pyrazole and pyrazoline derivatives. Compounds with pyrazole ring are of interest due to their broad spectrum of biological activities against NOS inhibitor (Carrión et al., 2008), monoamine oxidase inhibitor (Gökhan-Kelekçi et al., 2009), antibacterial (Faria et al., 2017), antiamoebic (Abid et al., 2009). Moreover, -phenyl pyrazole derivatives play an N important role in antitumor screening (Naito et al, 2002) as well as potent antimicrobial activity (Farag et al., 2008a). Furthermore, several hydrazide-hydrazone derivatives also have been claimed to possess interesting bioactivity such as antifungal (Karrouchi et al., 2018), anticonvulsant (AbdelAziz et al., 2009), antiinfloammatory (Farag et al., 2008b), anticancer activities (Chalina et al., 1998)1, antiviral (Shih SR et al., 2010), and anticoagulant (Michon et al., 1995). The pyrazole derivatives play important roles in the development of pesticides, insecticides, and herbicides (Saad et al., 2011).