Comparison of serum and salivary enzyme creatine phosphokinase in patients with oral dysplasias

Djaynishanth Djanamezeane, Premraj Prahaspathy
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Abstract

Oral Epithelial Dysplasia (OED) appears as chronic, progressive, premaligant lesions of the oral mucosa, which are considered as the forerunner of Oral cancers, is a threat to the public accounting for increasing number of new cases and deaths worldwide, every year. Most of the oral cancers are detected at a late stage which is difficult to treat as well as has poor prognosis. The application of advanced molecular biological and biochemical methodologies to elucidate the biomarkers of these potentially malignant disorders may help in early detection of these lesions. A precise and more accurate marker which has the potential to predict the progression of a potentially malignant disorder to a malignant state, will enable early diagnosis as well as targeting of these lesions for the subsequent modification of treatment and follow up. One of the important molecular change which accompanies the transformation of a potentially malignant disorder involving the oral cavity to a malignant state is, elevation of serum levels of enzyme, Creatine Phosphokinase, which occurs on account of damage to the connective tissue cells and the deeper submucosal layers due to invasion by the malignant cells. The present study is undertaken to compare the levels of enzyme, Creatine phosphokinase in the serum and saliva of patients with oral dysplastic lesions and henceforth to assess the usefulness of these enzymes as a diagnostic marker of early transformation of these dysplastic lesions to a malignant state. Keywords: CPK, OED, PMD.
口腔发育不良患者血清和唾液肌酸磷酸激酶的比较
口腔上皮发育不良(OED)是一种慢性、进行性、原发性口腔粘膜病变,被认为是口腔癌的先兆,对公众构成威胁,每年在世界范围内造成越来越多的新病例和死亡。大多数口腔癌发现较晚,治疗困难,预后差。应用先进的分子生物学和生物化学方法来阐明这些潜在恶性疾病的生物标志物可能有助于这些病变的早期发现。一种精确和更准确的标记物有可能预测潜在恶性疾病向恶性状态的进展,将使早期诊断以及针对这些病变进行后续治疗和随访。伴随潜在的口腔恶性疾病向恶性状态转变的一个重要的分子变化是血清肌酸磷酸激酶水平的升高,这是由于恶性细胞入侵导致结缔组织细胞和更深的粘膜下层受损而发生的。本研究旨在比较口腔发育不良病变患者血清和唾液中酶、肌酸磷酸激酶的水平,从而评估这些酶作为这些发育不良病变早期转化为恶性状态的诊断标志物的有效性。关键词:CPK, OED, PMD。
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