Evaluation of Serum Metalloprotinase-9 (MMP-9) in Iraqi Men with urinary tract infection

Abstract

Objective: The inflammation of the urinary tract and its various causes is one of the important diseases, which neglect and non-treatment lead to many amplifications, therefore, many countries including the United States of America has given urinary tract infection ″ UTI ″ a great interest. Since the disease is sometimes without obvious symptoms and because of research lacking that are using MMP-9 . The aim of this work is to study the alterations in the Metalloprotinase-9 (MMP-9), and its role in pathogenicity of urinary tract infections ″UTI″ in serum of men who are initially diagnosed with this disease. Methods: This study was applied in educational Alsader hospital in Najaf city by using Enzyme Linked Immuno Sorbent Assay (ELISA) on serum taken from 42 men infected with UTI, and other 38 healthy considered as a control group to detect MMP-9. Data analysis: SPSS computerizing system has been used for statistically analysis of data . Results: The results revealed a highly significant (P<0. 05) level of ″MMP-9″in serum of patients in comparison with the control group. The result also demonstrated the strong relation between MMP-9 and other parameters such as age and smoking. Conclusion: It was concluded from the results of the present study thatMetalloprotinase-9″MMP-9″ was good prognostic biomarker for ″UTI″ in men, and these results significantly correlate with the early stages of disease. Recommendation: 1-It may be recommended that using MMP-9 to predict and diagnosis the urinary tract infection. 2-It may be also recommended to measure MMP-9 in women to establish its role in this disease