Review on Nanosponges- A Versatile Drug Delivery System

Abstract

Target effective drug delivery systems are the novel approach for delivering various active moieties to targeted site. Targeting active moieties to a specific site is achieved by appropriate nanotechnology as targeted drug delivery system has various drawbacks. In order to combat this problem various dosage forms have been developed with nanotechnology among those the one with discrete functionalized particles are called as Nanosponges. Nanosponges are porous polymeric nanoparticles which are spherical in shape about a size of virus and can load wide variety of drugs. These nanoparticles with nanosize circulate rapidly in the body till they achieve specific target site and release drug in predictable and sustained manner. A detailed introduction about nanosponges and its various advantages when compared with vesicular systems, its mechanism of drug release, various drugs formulated as nanosponges, preparation and evaluations of nanosponges with applications in pharmacy are provided. This article provides a clear cut view of nanosponges and its targeted delivery, by which drugs with low solubility, bioavailability and adverse effects can easily formulated by overcoming all these problems. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Harsha, G.; Shaik, N.B. Review on NanospongesA Versatile Drug Delivery System. Indo Global J. Pharm. Sci., 2021; 11(1): 47-55. DOI: http://doi.org/10.35652/IGJPS.2021.111007 . Indo Global Journal of Pharmaceutical Sciences, 2021; 11(1): 47-55 48 colloidal nature and reported to have high solubilization capacity of poorly water soluble drug which provide sustained release as well as improving drug bioavailability. Because of their inner hydrophobic and outer hydrophilic branching, they are able to load both hydrophilic and hydrophobic drug molecules offering unparalleled flexibility[4]. COMPOSITION AND STRUCTURE OF