Cellulose nanocrystal reinforced silk fibroin coating for enhanced corrosion protection and biocompatibility of Mg-based alloys for orthopedic implant applications

IF 7.9 2区材料科学 Q1 CHEMISTRY, APPLIED

Progress in Organic Coatings Pub Date : 2021-12-01 Epub Date: 2021-09-23 DOI:10.1016/j.porgcoat.2021.106525

Hamid Asadi, Sama Ghalei, Hitesh Handa, Ramaraja P. Ramasamy

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引用次数: 13

Abstract

In this work, a novel coating material based on silk fibroin (SF) and cellulose nanocrystals (CNCs) was developed on biodegradable AZ31 Mg alloy and assessed for corrosion resistance and biocompatibility. Before the application of the coating, AZ31 substrate was modified with a layer of polydopamine to enhance the adhesion of the protective coating to the metal surface as confirmed by the adhesion tape test. SEM images revealed the formation of a defect-free and uniform SF-CNC coating with a thickness of 11.2 ± 2.5 μm on AZ31 alloy. The results of the electrochemical corrosion and in vitro immersion tests clearly demonstrated an enhanced corrosion resistance of the SF coating after the incorporation of CNCs. Compared to the unmodified Mg alloy, the SF-CNC coated AZ31 exhibited a remarkably improved cytocompatibility with a viability of 114% and excellent adhesion and spreading of human fetal osteoblast cells onto the coating surface. The findings of this work highlight the great potential of SF and CNC as bio-based nature-derived anticorrosive nanofillers for fabrication of protective and biocompatible coatings on Mg-based biodegradable orthopedic implants.

Abstract Image

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纤维素纳米晶增强丝素蛋白涂层增强腐蚀保护和生物相容性的镁基合金矫形植入物应用

本研究在可生物降解的AZ31镁合金上制备了一种基于丝素蛋白(SF)和纤维素纳米晶体(cnc)的新型涂层材料，并对其耐腐蚀性和生物相容性进行了评估。在涂层应用前，对AZ31基材进行一层聚多巴胺修饰，通过粘接胶带测试证实，可以增强保护涂层对金属表面的附着力。SEM图像显示，在AZ31合金表面形成了一层厚度为11.2±2.5 μm、无缺陷、均匀的SF-CNC涂层。电化学腐蚀和体外浸渍试验的结果清楚地表明，加入cnc后，SF涂层的耐腐蚀性增强。与未修饰的镁合金相比，SF-CNC涂层AZ31的细胞相容性显著提高，存活率为114%，并且人胎成骨细胞在涂层表面具有良好的粘附和扩散能力。这项工作的发现突出了SF和CNC作为生物基天然衍生的防腐纳米填料的巨大潜力，可用于制造mg基可生物降解骨科植入物的保护性和生物相容性涂层。

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来源期刊

Progress in Organic Coatings 工程技术-材料科学：膜

CiteScore

11.40

自引率

15.20%

发文量

577

审稿时长

48 days

期刊介绍： The aim of this international journal is to analyse and publicise the progress and current state of knowledge in the field of organic coatings and related materials. The Editors and the Editorial Board members will solicit both review and research papers from academic and industrial scientists who are actively engaged in research and development or, in the case of review papers, have extensive experience in the subject to be reviewed. Unsolicited manuscripts will be accepted if they meet the journal''s requirements. The journal publishes papers dealing with such subjects as: • Chemical, physical and technological properties of organic coatings and related materials • Problems and methods of preparation, manufacture and application of these materials • Performance, testing and analysis.