Comparative study of Clinicolaboratory parameters of dengue in diabetic and non-diabetic from a tertiary care hospital

Abstract

Dengue, neglected tropical disease, caused by a RNA virus belonging to Flaviviridae family. Comorbid conditions like diabetes mellitus, can lead to severe dengue leading to higher morbidity and mortality. This study was undertaken to compare the clinical and laboratory profile of dengue patients with and without diabetes mellitus. A retrospective study conducted at the tertiary care hospital. The clinical and laboratory details of the adult patients diagnosed with dengue from January 2014 to March 2019 were included in the studied. The data was entered in Microsoft excel and analyzed. We have analyzed the hematological, hepatic and renal parameters in three groups: healthy individuals (n= 80), patients with diabetes (n= 66) and dengue (n= 422). Among the patients diagnosed with dengue, 393/422 (93. 12%) survived. Among the dengue patients who were diabetic (129), 115 (89. 14%) survived and 14 (10. 85%) succumbed. The most common symptoms in dengue patients were fever (100%), vomiting (53. 32%) and body ache (51. 9%). In deceased patients, symptoms of severe dengue like reduced urine output, bleeding manifestations, pedal oedema, altered sensorium were noted. Signs of fluid leak like ascites and pleural effusion were higher in deceased patients. Among the deceased patients, anaemia, thrombocytopenia, increased renal parameters were observed in diabetic patients. Dengue in diabetic patients is associated with anemia, thrombocytopenia and higher mortality. There is no significant difference in hepatic and renal parameters in survived dengue diabetic and non-diabetic patients, but deceased patients had significant thrombocytopenia and increased renal parameters.