Formation and Development of Ondansetron Hydrochloride Nasal in situ gel

Abstract

http://dx.doi.org/10.21276/IJRDPL.22780238.2018.7(5).3100-3103 ABSTRACT: Objective: In view of the present study, the object of the study was to formulate and evaluate nasal in situ gel contains Ondansetron hydrochloride. Methodology: Ondansetron hydrochloride loaded colloidal dispersion were prepared for nasal drug delivery using various polymers like carbopol (0.4%) and HPMC (1%) concentrations. The optimized formulation contains benzalkonium chloride as a preservative, sodium chloride as a tonicity adjuster, 0.5 M NaOH to maintain pH. The finished formulation was characterized for its clarity, pH, viscosity, drug content, net content, weight loss on storage, in vitro diffusion and in vitro bioadhesive strength. Result: Ondansetron hydrochloride was successfully formulated as a pH induced in situ gel for nasal administration and have potential to avoid first pass effect than oral route. Conclusion: The results of the study conclusively proved the suitability a nasal in situ gel of Ondansetron hydrochloride which was developed and formulated in this study is ideal for nasal administration for the treatment of antiemetic.