Effect of Carica papaya Leaves and Seeds on Electrolyte and Hematological Parameters in Albino Wistar Rats Exposed to Lead Nitrate

A. J. Okon, O. Aluko, Idorenyin Jonathan Okon, S. Inah, Afe Dania, Favour Inyang-ogim Achi
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Abstract

Background: Exposure to lead produces a variety of adverse health effects. This study evaluated the effect of aqueous extracts of Carica papaya leaves and seeds on electrolyte and hematological parameters in albino Wistar rats exposed to lead nitrate. Methods: Thirty male albino Wistar rats weighing between 174- 196g were assigned to six groups of five animals. Group 1 served as control, group 2 received 50mg/kg body weight lead nitrate (PbNO3), groups 3 and 4 received 500 mg/kg body weight aqueous extract of Carica papaya leaves (CPL) and Carica papaya seed (CPS) respectively, groups 5 and 6 received 50mg/kg body weight PbNO3 + 500mg/kg body weight CPL and CPS respectively for 31 days by oral gavaging. Animals were sacrificed and blood collected for various assay using standard methods. ANOVA on SPSS version 25 was used to determine variations within and between groups. Results: Increases in sodium and potassium, and decreases in chloride, calcium and bicarbonate levels were observed in the lead intoxicated group. Treatment with CPL and CPS reversed the alterations in electrolytes. Levels of RBC, PCV, Hb, MCH, MCHC and lymphocytes were lower in the lead intoxicated group relative to the lead intoxicated groups complemented with CPL and CPS, while WBC, MCV and platelet counts were higher in the lead intoxicated group when compared to the group complemented with CPL and CPS. Conclusion: This finding suggests that CPL and CPS could be protective against lead induced alterations in electrolytes and hematological parameters and could be harnessed for these potentials.
木瓜叶和种子对暴露于硝酸铅的白化Wistar大鼠电解质和血液学参数的影响
背景:接触铅会产生各种不利的健康影响。本研究评价了番木瓜叶和种子水提物对硝酸铅暴露的白化Wistar大鼠电解质和血液学参数的影响。方法:体重174 ~ 196g的雄性白化Wistar大鼠30只,随机分为6组,每组5只。1组作为对照组,2组给予50mg/kg体重硝酸铅(PbNO3), 3组和4组分别给予500mg/kg体重番木瓜叶(CPL)和番木瓜籽(CPS)水提物,5组和6组分别给予50mg/kg体重PbNO3 + 500mg/kg体重CPL和CPS灌胃31 d。用标准方法宰杀动物,采集血液进行各种化验。采用SPSS版本25上的方差分析来确定组内和组间的变化。结果:铅中毒组钠、钾含量升高,氯、钙、碳酸氢盐含量降低。CPL和CPS治疗逆转了电解质的变化。铅中毒组红细胞、PCV、Hb、MCH、MCHC和淋巴细胞水平较CPL和CPS组低,而WBC、MCV和血小板计数较CPL和CPS组高。结论:CPL和CPS对铅诱导的电解质和血液学参数的改变具有保护作用,可以用于这些电位。
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