The Mannich Reaction in Imidazo [1,2-a] Pyridine Series Assisted by Microwave

Abstract

A comparative studying for the preparation of new compounds in series Imidazo [1,2-a] pyridine via the Mannich reaction which was carried out. Mannich bases, 3 to 6, were synthesized under standard conditions (conventional heating) or microwave irradiation (MW), by action of secondary amines on 2-methyl imidazo [1,2-a] pyridine 1 in the presence of formaldehyde. The results show synthesis under different conditions, for the first time, the training side of Mannich bases of 7 dimer resulting from the condensation of two moles of compound 1 and a mole of formaldehyde with very variable yields. For compound 3, for example,it is about 100%. Our study shows, whenthat we are preparing the initial substrate under MW irradiation, the presence of a compound 2 of the same molecular weight in the trace