The Effect of Green Coffee Supplement on Glycemic Control, Inflammatory Index, Lipid Profile, and Anthropometry in Type II Diabetic Patients

Abstract

This study was conducted to determine the effects of green coffee supplementation on glycemic control, oxidative stress, lipid profile and anthropometry measurements in patients with type 2 diabetes. The present study is a randomized clinical trial. 60 diabetic patients were randomly divided into intervention and control groups. Patients received green coffee extract daily for 8 weeks 800 mg supplement capsule (two 400 mg capsules per day). The control group received two placebo capsules daily. The variables evaluated included demographic and anthropometry information, physical activity according to the IPAQ questionnaire, 24-hour food recall (beginning, half and end of the study) and lipid profile, fasting blood sugar, serum insulin, HOMA-IR and TAC before and at the end of the eighth week, it was evaluated in all patients. The mean body weight, Body Mass Index (BMI), and waist circumference at the beginning and end of the study did not differ significantly between the two groups (P-values<0.05). The mean fasting blood sugar in the coffee group at the end of the study was significantly reduced compared with the placebo group (P-value=0.0001). The mean serum insulin in the coffee group at the end of the study was significantly reduced compared with the placebo group (P-value=0.003). Moreover, the mean HOMA-IR at the end of the study in the coffee group was significantly reduced compared with the placebo group (P-value=0.003). LDL and total cholesterol in the coffee group at the end of the study were significantly reduced compared with the placebo group (P-values=0.003). The mean triglyceride at the end of the study was not significantly different in the coffee group (P-values=0.15). The mean TAC at the end of the study in the coffee group was significantly higher than the placebo group (Pvalue=0.0001). To sum up, the use of green coffee supplement which reduced the fasting blood sugar and insulin sensitivity and improved the blood lipid profile and TAC in type 2 diabetic patients. But it had no effect on weight, waist circumference, Body Mass Index (BMI) and triglyceride levels. Green coffee supplement can be considered as an adjunct in the control of diabetes in patients.