The effect of low dose teophillyne on the improvement of copd assessment test score, interleukin-8 level and sputum neutrophil count in patients with stable COPD

Y. Sutanto, M. Sutanto, Hendra - Kurniawan
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Abstract

Background: Harmful particles from cigarette smoke induces an inflammatory immune response in the lungs, followed by the release of proinflammatory cytokines such as TNF-α and IL-8 and damages histone deacetylase 2 (HDAC2) in the cell core leading to glucocorticoid resistance in COPD.  Low dose Theophylline of below 10mg/L has an anti-inflammatory effect by activating HDAC.  This study aimed to analyze the effect of low dose theophylline on the clinical improvement of stable COPD patients assessed by the COPD Assessment Test (CAT) score, IL-8 level, and sputum neutrophil count.Methods: We conducted a quasi-experimental clinical study using a pre-post test in stable COPD patients visiting the Pulmonary Outpatient Clinic of  DR. Moewardi hospital Surakarta, between July and September 2016.  The samples were taken using a consecutive sampling technique, assigned into two groups, treatment, receiving standard therapy plus 70 mg low dose theophylline per 8 hours, and control receiving standard therapy only.  CAT score, IL-8 level, and sputum neutrophil count were measured at baseline and four weeks after treatment.Results: The treatment group's CAT score decreased by 3.67±3.58 pg/ml and increased by 2.40±3.38 pg/ml in the control group (p=0.003).  IL-8 level decreased by 4.31±13.06 pg/ml in the treatment group and increased by 0.88±13.89 pg/ml in the control group (p=0.116).  The sputum neutrophil count decreased in both treatment and control groups by 4.00 ±40.33 pg/ml and 2. 87±39. 91 pg/ml (p=0.939).Conclusion: Statistically low dose theophylline significantly lowers the CAT score of stable COPD patients. It also decreases IL-8 level and sputum neutrophil count, although it is not significant.
低剂量茶啡碱对稳定期copd患者copd评估试验评分、白细胞介素-8水平及痰中性粒细胞计数的改善作用
背景:来自香烟烟雾的有害颗粒在肺部诱导炎症免疫反应,随后释放促炎细胞因子如TNF-α和IL-8,并破坏细胞核心的组蛋白去乙酰化酶2 (HDAC2),导致COPD患者糖皮质激素抵抗。低剂量茶碱10mg/L以下通过激活HDAC具有抗炎作用。本研究旨在通过COPD评估试验(COPD Assessment Test, CAT)评分、IL-8水平、痰中性粒细胞计数评估低剂量茶碱对稳定期COPD患者临床改善的影响。方法:我们对2016年7月至9月在泗水DR. Moewardi医院肺病门诊就诊的稳定期COPD患者进行了一项准实验性临床研究。样品采用连续取样技术,分为两组,治疗组接受标准治疗加每8小时70 mg低剂量茶碱,对照组只接受标准治疗。在基线和治疗后4周测量CAT评分、IL-8水平和痰中性粒细胞计数。结果:治疗组CAT评分降低3.67±3.58 pg/ml,对照组升高2.40±3.38 pg/ml (p=0.003)。治疗组IL-8水平降低4.31±13.06 pg/ml,对照组升高0.88±13.89 pg/ml (p=0.116)。治疗组和对照组痰中性粒细胞计数分别下降4.00±40.33 pg/ml和2。87±39。91 pg/ml (p=0.939)。结论:低剂量茶碱可显著降低稳定期COPD患者CAT评分。它还能降低IL-8水平和痰中性粒细胞计数,尽管作用不显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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12 weeks
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