Potential Plants for Treatment and Management of COVID-19 in Nigeria

B. C. I. Chiyere, O. Tochukwu, C. Enyoh, J. Uju
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引用次数: 9

Abstract

The recent outburst of novel Coronavirus disease (COVID-19), now a global pandemic highlights an urgent need for therapeutics targeting ‘severe acute respiratory syndrome’ (SARS-CoV-2). In Nigeria, infection cases are on daily rise with death rate of ~3 %. Therefore, slowing the spread of the virus will significantly reduce the strain on the healthcare system and governments. Here, we presented local medicinal plants cultivated in Nigeria as possible therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. The study focused on some plants containing bioactive compounds that showed promising results against previous coronaviruses. Potential plants identified include Zingiber officinale, Allium cepa, Allium sativum, echinacea, euphorbia hirta, Garcenea kola, Curcuma longa, Aleo vera and olea europaea. Although inhibition of viral replication is seen as the possible mechanism for antiviral activity of most of the natural compounds, recent research has shown that some natural compounds can interact with major viral proteins associated with virulence. Thereby, showing they could be a valuable tool for possible inhibition, management and treatment of SARS-CoV-2. However, further research is required to investigate and validate their potential use as anti-SARS-CoV-2.
尼日利亚治疗和管理COVID-19的潜在植物
最近爆发的新型冠状病毒病(COVID-19),现在已成为全球大流行,迫切需要针对“严重急性呼吸系统综合征”(SARS-CoV-2)的治疗方法。在尼日利亚,感染病例每天都在上升,死亡率约为3%。因此,减缓病毒的传播将大大减轻卫生保健系统和政府的压力。在这里,我们介绍了在尼日利亚种植的当地药用植物作为可能的治疗方法,专门针对SARS-CoV-2及其途径。这项研究的重点是一些含有生物活性化合物的植物,这些植物对以前的冠状病毒显示出有希望的效果。已确定的潜在植物包括生姜、葱、葱、紫锥菊、大戟、栀子花、姜黄、芦荟和油橄榄。虽然抑制病毒复制被认为是大多数天然化合物抗病毒活性的可能机制,但最近的研究表明,一些天然化合物可以与与毒力相关的主要病毒蛋白相互作用。因此,表明它们可能是抑制、管理和治疗SARS-CoV-2的有价值的工具。然而,需要进一步的研究来调查和验证它们作为抗sars - cov -2的潜在用途。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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