Oxidative stress biomarkers among Saudi patients withnon-alcoholic steatohepatitis versus chronic hepatitis C

O. Al-Jiffri
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引用次数: 3

Abstract

Introduction:As oxidative status may be an influential factor for increasing the progress of the disease and decreasing the effectiveness of the treatment, the aim of this study was to measure the oxidative stress and anti-oxidative markers among Saudi patients with chronic hepatitis C (CHC) versus nonalcoholic steatohepatitis (NASH).Material and Methods:This study was carried out on a sample of 150 consecutive patients (75 with CHC and 75 with NASH), selected from gastroenterology outpatient clinic, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Also, this study included 75 healthy volunteers, mostly, relatives of the patients who came with them to the clinic. Measurements of oxidative stress and anti-oxidative stress markers were measured for all participants.Results:The mean values of oxidative stress markers included conjugated dienes (CD), malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) were significantly elevated in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly elevated in patients with NASH than patients with CHC. However, the mean values of anti-oxidative stress markers include glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH), arylesterase (AE) and paraoxonase (PON) were significantly reduced in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly reduced in patients with NASH than patients with CHC.Conclusions:In this study, patients with NASH have higher levels of oxidative and lower anti-oxidant markers than patients with CHCs.
沙特非酒精性脂肪性肝炎患者与慢性丙型肝炎患者的氧化应激生物标志物
由于氧化状态可能是增加疾病进展和降低治疗有效性的一个影响因素,本研究的目的是测量沙特慢性丙型肝炎(CHC)患者与非酒精性脂肪性肝炎(NASH)患者的氧化应激和抗氧化标志物。材料和方法:本研究选取了来自沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院消化科门诊的150例连续患者(75例CHC和75例NASH)作为样本。此外,这项研究还包括75名健康的志愿者,其中大多数是与他们一起来到诊所的患者的亲属。测量所有参与者的氧化应激和抗氧化应激标志物。结果:CHC和NASH患者的氧化应激标志物包括共轭二烯(CD)、丙二醛(MDA)、一氧化氮(NO)和髓过氧化物酶(MPO)的平均值与健康对照组相比显著升高。此外,NASH患者的这些参数明显高于CHC患者。然而,CHC和NASH患者抗氧化应激标志物谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、芳基酯酶(AE)和对氧磷酶(PON)的平均值与健康对照组相比均显著降低。此外,NASH患者的这些参数明显低于CHC患者。结论:在本研究中,NASH患者的氧化标志物水平高于CHCs患者,而抗氧化标志物水平较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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