Association of bipolar I disorder with obsessive compulsive disorder: A clinical study from Pakistan

Q3 Medicine
Qurat ul ain Khan , Sana Younus , Hania Hasan , Muhammad Zaman Khan
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引用次数: 2

Abstract

Background

The association and/or comorbidity of bipolar I disorder I (BD I) with obsessive compulsive disorder (OCD) is discussed in the literature. This association is under-recognized in Pakistan causing management problems. This is the first study reporting this association in Pakistan.

Method

Retrospective data collection of 500 patients consecutively diagnosed with BD I according to DSM IV-TR was done in inpatient and outpatient settings at a tertiary care setting in Karachi, Pakistan; 469 patients who fulfilled the criteria were included in the study. Patients with BD I with and without OCD were compared for demographics, presenting symptoms, duration of disease, differences in treatment, and other clinical variables.

Results

35 (7.5%) of the 469 patients had OCD along with BD I, with more than half having bipolar as the first diagnosis. A majority of the BD I−OCD patients had OCD symptoms during manic phase or in remission, with contamination as the main theme. The BD I−OCD group had a lower level of education, higher divorce rates, a higher incidence of OCD, as well as BD in the family, longer duration of illness, and fewer medical comorbidities.

Limitations

This is a retrospective study with patients from both inpatient and outpatient settings from a tertiary care hospital.

Conclusion

The association of BD I with OCD needs to be recognized by clinicians, as presentation may be different in this group especially in contextualized settings in Pakistan, where OCD or OCD-like symptoms may be related to BD itself. This finding has important diagnostic and management implications.

双相I型障碍与强迫症的关联:一项来自巴基斯坦的临床研究
文献中讨论了双相I型障碍(BD I)与强迫症(OCD)的关联和/或共病。这种联系在巴基斯坦没有得到充分认识,造成了管理问题。这是巴基斯坦首次报道这种关联。方法回顾性收集500例根据DSM IV-TR连续诊断为BD I的患者的数据,这些患者分别来自巴基斯坦卡拉奇一家三级医疗机构的住院和门诊;469名符合标准的患者被纳入研究。对伴有和不伴有强迫症的双相障碍I患者进行人口统计学、症状、病程、治疗差异和其他临床变量的比较。结果469例患者中有35例(7.5%)患有强迫症合并双相障碍,其中超过一半的患者首次诊断为双相障碍。大多数BD I - OCD患者在躁狂期或缓解期有强迫症症状,以污染为主要主题。BD I - OCD组受教育程度较低,离婚率较高,强迫症发病率较高,家庭中也有BD,病程较长,医疗合并症较少。局限性:这是一项回顾性研究,来自三级保健医院的住院和门诊患者。结论临床医生需要认识到双相障碍I与强迫症的关系,因为这一群体的表现可能不同,特别是在巴基斯坦的情境环境中,强迫症或强迫症样症状可能与双相障碍本身有关。这一发现具有重要的诊断和管理意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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期刊介绍: Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.
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