Endothelin and prostate cancer

Abstract

Endothelin is the strongest vasoconstrictor and has extensive biological functions.Recently Endothelin has been re- ported to be mitogenic and anti-apoptotic for prostate cancer cell.And it is also found that but endothelin can induce angiopoiesis in the cancer tissue.Additionally,endothelin has been confirmed to be involved in cancer metastasis and cancer pain.These all suggest that en- dothelin plays an important role in the onset and process of the prostate cancer.