Snail-parasite compatibility and prevalence of Schistosoma haematobium on the shores of Lake Kariba, Zambia

Abstract

Abstract Reduced snail-parasite compatibility might be at least partially responsible for the decrease observed, over the last three decades, in the prevalence of urinary schistosomiasis on the shores of Lake Kariba, Zambia. To explore this possibility, the prevalences of urinary schistosomiasis in schoolchildren were investigated in three disparate areas of Zambia (Lake Kariba, Lake Bangweulu and Lusaka), and attempts were made to infect the snails that developed from the eggs of snails collected from each of these sites with Schistosoma haematobium from each of the sites. The prevalence of S. haematobium infection in schoolchildren ranged from 0% around Lake Bangweulu to 76% around Lake Kariba. The F1 progeny of Siavonga (Lake Kariba) snails showed good compatibility with the local parasite but were also susceptible to all of the geographical strains of S. haematobium tested. The interaction between the S. haematobium and S. mansoni found along the shores of Lake Kariba may favour S. mansoni, since prevalences of urinary schistosomiasis tend to be relatively high where S. mansoni is absent. Although Lake Bangweulu was confirmed to be an area of very low endemicity for urinary schistosomiasis, the snails bred from snails collected in this area were compatible with isolates of S. haematobium from the same region and also those from the other regions. In general, sympatric snail-parasite combinations were the most successful. All the snails were identified as Bulinus globosus, on the basis of common enzyme profiles, although polymorphism was evident for malate dehydrogenase (MDH): two samples had type-1 MDH and the rest were of type 3. Isoenzyme patterns for both acid phosphatase (AcP) and MDH could be used to distinguish between infected and uninfected snails.