A polyherbal formulation containing Justicia pectoralis Jacq., Achyrocline satureioides (Lam.) DC., and Eclipta prostrata (L.) L. helped reducing symptom intensity during and after Covid-19 infection: A retrospective, uncontrolled observational study

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2023-09-01 DOI:10.1016/j.aimed.2023.07.004

Fabio Carmona , Lucas Chaves , Fabiana Cardoso Tardelli do Nascimento , Débora Simone Sales , Bianca Waléria Bertoni , Gustavo Henrique Teixeira Pinto , Pedro de Pádua Amatto G. , Ana Maria Soares Pereira

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引用次数: 0

Abstract

Objectives

To retrospectively describe a local experience with a polyherbal formulation on reducing the symptoms of Covid-19 and the need for hospitalization. The formulation contained three species traditionally used for respiratory symptoms: Justicia pectoralis Jacq. (Acanthaceae, “chambá” or “tilo”), Achyrocline satureioides (Lam.) DC. (Asteraceae, “macela”), and Eclipta prostrata (L.) L. (Asteraceae, “erva-botão” or “bhringraj”, synonym Eclipta alba L.).

Design

Observational, retrospective study.

Methods

More than 2000 adults with suspected Covid-19 received a polyherbal formulation with J. pectoralis, A. satureioides, and E. prostrata. About 20% of them were contacted by phone in an observational, retrospective study to assess the effects on symptom relief and hospitalizations. Two hundred patients were included. The identities and concentrations of the main compounds in the three species were determined using high-performance liquid chromatography (HPLC).

Results

Participants reported substantial improvement in the following symptoms: weakness, pain, cough, headache, dysgeusia, anosmia, fever, dyspnea, odynophagia, diarrhea, chest pain, and conjunctivitis. The need for hospitalization was not significantly lower than the one found in the Brazilian population with Covid-19. The main compounds in the species were: quercetin, luteolin, and 3-O-methylquercetin in A. satureioides; umbelliferone and coumarin in J. pectoralis; and demethylwedelolactone and wedelolactone in E. prostrata.

Conclusions

A polyherbal formulation containing J. pectoralis, A. satureioides, and E. prostrata helped relieving symptoms of Covid-19 but did not reduce the need for hospitalization.

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一种含有胸凤仙花的复方制剂。、类饱和甲环素(Lam.)直流。和赤月食(L.)L.帮助减轻Covid-19感染期间和之后的症状强度:一项回顾性、不受控制的观察性研究

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.