The value of NIPT combined with serum cell-free DNA, estriol, AFP, and b-HCG levels in the recognition of trisomy 21 and 18 in the second trimester.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2023-10-27 DOI:10.5937/jomb0-33027

JingLi Fu, XiaoYan Zhong, Dan Li, YunSheng Ge, XueQin Zhang

引用次数: 0

Abstract

Background: This study aimed to evaluate the clinical application value of noninvasive prenatal testing from DNA (NIPT) and serum screening for screening in detecting fetal trisomy 21 and 18.

Methods: As a retrospective analysis, we collected data from 1383 women (singleton pregnancy) who underwent serum screening and noninvasive prenatal testing from DNA (NIPT) in our department from May 2015 to September 2017 and calculated the diagnostic value of the two methods.

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NIPT 与血清无细胞 DNA、雌三醇、甲胎蛋白和 b-HCG 水平相结合，对识别第二孕期 21 和 18 三体综合征的价值。

背景：本研究旨在评估DNA无创产前检测（NIPT）和血清筛查在检测胎儿21和18三体综合征方面的临床应用价值：本研究旨在评估DNA无创产前检测（NIPT）和血清筛查在检测胎儿21和18三体综合征方面的临床应用价值：作为一项回顾性分析，我们收集了2015年5月至2017年9月在我科接受血清筛查和DNA无创产前检测（NIPT）的1383名妇女（单胎妊娠）的数据，并计算了两种方法的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.