The ANTI-QUORUM SENSING AND ANTITUMOR ACTIVITY OF PRUNELLA VULGARIS, SAMBUCUS NIGRA, CALENDULA OFFICINALIS: potential use in food industry potential use in food industry

Melike Nur Tosun, N. N. Zorba, Y. Yüceer
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引用次数: 6

Abstract

With the emergence of health related side effects of synthetic substances, the trend towards natural products has increased and has directed researchers to determine their pharmacological properties. At the same time, the resistance of the microorganisms to the antibiotics used in the treatment revealed that they should be controlled without allowing them to gain resistance. In this study, the total phenolic content, volatile composition and antioxidant, antimicrobial, anti-quorum sensing and antitumor activities of Prunella vulgaris, Sambucus nigra and Calendula officinalis extracts were determined. The antioxidant capacity of the extracts was determined by the Trolox Equivalent Antioxidant Capacity (TEAC) method, volatile component analyses were determined by GC-MS, and antimicrobial activity was determined by the disc diffusion method. Chromobacterium violaceum 026 and Agrobacterium tumefaciens A136 were used to determine the anti-quorum sensing activity. Additionally, the antitumor potential of the extracts was determined by the potato disc method. Prunella vulgaris was the plant with the highest antioxidant capacity, while the extract with the highest antimicrobial activity was determined to be Sambucus nigra against Staphylococcus aureus ATCC 25923. The results showed that all extracts have anti-quorum sensing properties. Prunella vulgaris was the plant with the highest anti-quorum sensing properties. There was a correlation between the extract concentration and tumor inhibition. The Prunella vulgaris extract was found to have the highest antitumor activity. As a result, it was determined that the plants used in the study have the potential to be used in alternative medicine treatment and can be utilized for the control of microorganisms.
夏枯草、黑荆、金盏菊的抗群体感应和抗肿瘤活性:在食品工业中的潜在应用
随着合成物质与健康有关的副作用的出现,使用天然产品的趋势有所增加,并指导研究人员确定其药理学特性。与此同时,微生物对治疗中使用的抗生素的耐药性表明,它们应该得到控制,而不允许它们产生耐药性。本研究测定了夏枯草、黑荆和金盏花提取物的总酚含量、挥发性成分以及抗氧化、抗菌、抗群体感应和抗肿瘤活性。采用Trolox等效抗氧化能力(TEAC)法测定提取物的抗氧化能力,采用GC-MS法测定挥发性成分,采用圆盘扩散法测定其抑菌活性。以紫色杆菌026和农杆菌A136检测其抗群体感应活性。此外,采用马铃薯圆盘法测定了提取物的抗肿瘤活性。结果表明,夏枯草抗氧化能力最强,黑参提取物对金黄色葡萄球菌ATCC 25923的抑菌活性最强。结果表明,所有提取物均具有抗群体感应特性。夏枯草的反群体感应性能最高。提取物浓度与肿瘤抑制作用存在相关性。夏枯草提取物的抗肿瘤活性最高。因此,确定研究中使用的植物具有替代医学治疗的潜力,并可用于微生物的控制。
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