Association of KIF1B (rs10492972) gene polymorphism with clinical phenotype and treatment response in multiple sclerosis in the case of Tomsk region population

Abstract

The relationship was studied between the rs10492972 polymorphism of the KIF1B gene and the risk of multiple sclerosis (MS), clinical phenotype of disease and response to disease modifying drugs (DMD) treatment in the patient’s population of Tomsk region. The study group included 152 patients; the control group consisted of 689 healthy volunteers. The results showed the impact of the risk allele C of KIF1B (rs10492972) gene polymorphism on the progressive forms of MS development (especially on primary progressive MS), and the relationship of the T allele with an early onset and relapsing-remitting course. The risk allele C also showed an association with the lack of response to second-line DMD therapy. The results of our study confirmed the association of the KIF1B (rs10492972) gene’s allele C with an unfavorable course of MS.