The level of adipokines in young people with hypertension and abdominal obesity

Q4 Medicine

Arterial Hypertension (Russian Federation) Pub Date : 2022-11-14 DOI:10.18705/1607-419x-2022-28-6-51-57

Y. Polonskaya, E. Kashtanova, E. Stakhneva, V. Shramko, E. Sadovski, L. Shcherbakova, A. Khudyakova, Y. Ragino

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Abstract

Objective. To investigate the adipokine blood profile in young people with hypertension (HTN) and abdominal obesity (AO). Design and methods. In total. 530 people were included in the study, including 267 people with HTN, of which 169 had AO. In the control group (without HTN) there were 263 people comparable to the study group by gender and age. Among them there were 106 people with AO. The blood levels of adiponectin, adipsin, lipocalin-2, resistin and plasminogen activator inhibitor-1 (PAI-1) were determined in all examined patients by multiplex analysis. Statistical data processing was carried out with the use of SPSS 13.0 program. Results. The levels of adiponectin and lipocalin-2 were lower in the group of HTN patients by 1,46 (p < 0,01) and 1,14 times (p < 0,05), respectively. The level of adipsin in HTN patients was significantly higher (p < 0,01) by 19,14 % compared to the control. The levels of resistin and PAI- did not differ in the control group and the group with HTN. Adiponectin level was 1,35 times lower (p < 0,05) in the group with AO compared to those without AO, the other indicators did not differ in the AO group and controls. In the HTN group, higher levels of PAI-1 were found in the subgroup with AO. When comparing the subgroup without HTN and without AO with the subgroup with HTN and AO, a significant decrease in concentration of adiponectin and lipocalin-2 was found. For the subgroups with AO, a decrease in adiponectin levels and an increase in adipsin levels (p < 0,01) were found in HTN patients. No statistically significant difference was found for the remaining indicators. The relative chance of early onset HTN was associated with the decrease in adiponectin and lipocalin-2 levels, and with the increase in adipsin levels, regardless of gender, age and the presence of AO. Conclusions. Thus, an increased level of adipsin and a reduced level of adiponectin and lipocalin-2 can serve as potential biomarkers indicating a high probability of developing early HTN in people under 45 years of age.

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青年人高血压和腹部肥胖的脂肪因子水平

目标。探讨青年高血压(HTN)和腹部肥胖(AO)患者的脂肪因子血谱。设计和方法。在总。530人参与了这项研究，其中267人患有HTN，其中169人患有AO。在对照组(没有HTN)中，有263人的性别和年龄与研究组相当。其中有106人患有AO。采用多重分析法测定患者血脂联素、脂素、脂联素-2、抵抗素和纤溶酶原激活物抑制剂-1 (PAI-1)水平。采用SPSS 13.0软件对统计数据进行处理。结果。HTN组脂联素和脂钙素-2水平分别降低1.46倍(p < 0.01)和1.14倍(p < 0.05)。与对照组相比，HTN患者的脂嘧啶水平显著升高(p < 0.01) 19.14%。抵抗素和PAI-水平在对照组和HTN组没有差异。AO组脂联素水平比未AO组低1.35倍(p < 0.05)，其他指标AO组与对照组无显著差异。在HTN组中，AO亚组中PAI-1水平较高。不含HTN和AO的亚组与含HTN和AO的亚组比较，脂联素和脂钙素-2浓度显著降低。在AO亚组中，HTN患者脂联素水平降低，脂素水平升高(p < 0.01)。其余指标的差异无统计学意义。早发HTN的相对几率与脂联素和脂联素-2水平的降低以及脂素水平的升高有关，与性别、年龄和AO的存在无关。结论。因此，脂肪素水平升高、脂联素和脂联素-2水平降低可以作为潜在的生物标志物，表明45岁以下人群发生早期HTN的可能性很高。

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来源期刊

Arterial Hypertension (Russian Federation) Medicine-Cardiology and Cardiovascular Medicine

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication. The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.