Evaluation the Effect of Sublingual Glutathione on the Quality of Life in COPD Patient by Using Saint George respiratory questionnaire

Abstract

Background: Chronic obstructive pulmonary disease (COPD)  is  a  chronic  inflammatory  disorder  of  the  airways associated  with  airway  narrowing  with  airflow  obstruction  leading to difficulty in breathing impair daily activity and cause poor quality of life. Patients  and  methods:  Fifty  patients whom  diagnosed with COPD are divided into   two  groups,  1st control group  includes  25 patients  assigned  to  receive  conventional  therapy of Formoterol fumarate 12 microgram inhaler twice daily,  and 2nd interventional group also includes  25  patients  assigned  to  receive  conventional  therapy with  (300 mg/ 2 times daily)   sublingual glutathione  for  two months. Saint George respiratory questionnaire (SGRQ) were  measured  before and after  first and second months after treatment  in  both  study groups. Aim  of  the  study: This  study  was  object to  assess the  changes  in quality of life by using SGRQ following sublingual glutathione supplements  therapy in COPD patients. Results and conclusion: After  two months  treatment ,  the  mean  values  of  SGRQ showed a significant  increase  compared  to  pre-treatment levels in  both  groups  (P<0.01).  There  was  highly  significant  improvement  in SGRQ in both  COPD  patients  groups after 2 months of treatment with much significant improvement in intervention group which may indicate the beneficial effects of adding glutathione sublingually administered supplements in COPD patients conventional therapeutic regiment.