Structural Changes in the Skeletal Muscle Fiber of Adult Male AlbinoRat Following Atorvastatin Treatment; the Possible Mechanisms ofAtorvastatin Induced Myotoxicity

Abstract

Method: Rats were divided randomly into four groups; each group included 6 rats: Group I, the control group, received distilled water. Group II received 10 mg/kg/day of atorvastatin. Group III received 40 mg/kg/day of atorvastatin. Group IV received 80 mg/kg/day of atorvastatin. Atorvastatin was given for 8 weeks. Vastus medialis muscle was taken out, rapidly fixed and processed for histological, histochemical and immunohistochemical studies.